Obesity is a major public health concern that has almost reached the level of pandemic and is rapidly progressing. Gut microbiota has emerged as a crucial regulator involved in the etiology of obesity, and the manipulation of it by dietary intervention has been widely used for reducing the risk of obesity. Nondigestible oligosaccharides (NDOs) are attracting increasing interests as prebiotics, as the indigestible ingredients can induce compositional or metabolic improvement to the gut microbiota, thereby improving gut health and giving rise to the production of short-chain fatty acids (SCFAs) to elicit metabolic effects on obesity. In this review, the role NDOs play in obesity intervention via modification of the gut microecology, as well as the physicochemical and physiological properties and industrial manufacture of NDOs, is discussed. Our goal is to provide a critical assessment of and stimulate comprehensive research into NDO use in obesity. Expected final online publication date for the Annual Review of Food Science and Technology, Volume 11 is March 25, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

中文翻译：

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不易消化的低聚糖对肥胖的影响。

肥胖是一个主要的公共卫生问题，几乎达到了大流行的程度，并且正在迅速发展。肠道微生物群已成为肥胖病因的关键调节因子，通过饮食干预对其进行控制已被广泛用于降低肥胖风险。不可消化的低聚糖 (NDO) 作为益生元越来越受到关注，因为不可消化的成分可以诱导肠道微生物群的组成或代谢改善，从而改善肠道健康并产生短链脂肪酸 (SCFA) 以引起代谢作用关于肥胖。在这篇综述中，讨论了 NDO 通过改变肠道微生态在肥胖干预中的作用，以及 NDO 的理化和生理特性以及工业制造。我们的目标是对 NDO 在肥胖症中的使用提供批判性评估并促进对 NDO 的综合研究。《食品科学与技术年度评论》第 11 卷的预计最终在线出版日期为 2020 年 3 月 25 日。请参阅 http://www.annualreviews.org/page/journal/pubdates 了解修订后的估计值。