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The Cystic Fibrosis Transmembrane Conductance Regulator 470 Met Allele Is Associated with an Increased Risk of Chronic Pancreatitis in Both Asian and Caucasian Populations: A Meta-Analysis.
Genetic Testing and Molecular Biomarkers ( IF 1.4 ) Pub Date : 2020-01-01 , DOI: 10.1089/gtmb.2019.0199 Donger Zhou 1 , Rui Bai 2 , Liang Wang 1
Genetic Testing and Molecular Biomarkers ( IF 1.4 ) Pub Date : 2020-01-01 , DOI: 10.1089/gtmb.2019.0199 Donger Zhou 1 , Rui Bai 2 , Liang Wang 1
Affiliation
Background: The Met470Val polymorphism (1540A>G [rs213950]) within the cystic fibrosis transmembrane conductance regulator (CFTR) protein has been reported to be associated with chronic pancreatitis (CP). The results remain inconclusive, and therefore, we performed this meta-analysis to clarify the association between M470V and CP risk. Methodology/Results: We conducted a meta-analysis of 7 case-control studies, including a total of 1121 CP patients and 2209 controls from Asian and Caucasian populations. We calculated the odds ratio (OR) and 95% confidence intervals (95% CI). Met470Val was found to be significantly associated with an increased risk of CP under all the genetic models (M vs. V, OR = 1.260, 95% CI: 1.134-1.399; MV vs. VV, OR = 1.292, 95% CI: 1.091-1.530; MM vs. VV, OR = 1.579, 95% CI: 1.274-1.956; MV/MV vs. VV, OR = 1.366, 95% CI: 1.165-1.603; MM vs. MV/VV, OR = 1.346, 95% CI: 1.114-1.621). Met470Val was also found to be significantly associated with an increased risk of idiopathic CP (ICP) in allele contrast, codominant, and recessive models (M vs. V, OR = 1.298, 95% CI: 1.020-1.653; MV vs. VV, OR = 1.297, 95% CI: 1.074-1.566; MM vs. VV, OR = 1.473, 95% CI: 1.165-1.862; MM vs. MV/VV, OR = 1.254, 95% CI: 1.023-1.538). Conclusions: The CFTR 470 M allele is significantly associated with an increased risk of CP in both Asian and Caucasian populations. The CFTR 470 M allele is also significantly associated with risk of ICP.
中文翻译：
囊性纤维化跨膜电导调节剂470 Met等位基因与亚洲和白种人人群患慢性胰腺炎的风险增加相关：一项荟萃分析。
背景：据报道，囊性纤维化跨膜电导调节剂（CFTR）蛋白中的Met470Val多态性（1540A> G [rs213950]）与慢性胰腺炎（CP）相关。结果仍然没有定论，因此，我们进行了这项荟萃分析以阐明M470V与CP风险之间的关联。方法/结果：我们对7个病例对照研究进行了荟萃分析，包括来自亚洲和白种人人群的1121名CP患者和2209名对照。我们计算了优势比（OR）和95％置信区间（95％CI）。在所有遗传模型下（M vs.V，OR = 1.260，95％CI：1.134-1.399; MV vs. VV，OR = 1.292，95％CI：1.091），发现Met470Val与CP风险增加显着相关-1.530; MM vs.VV，OR = 1.579，95％CI：1.274-1.956; MV / MV vs.VV，OR = 1.366，95％CI：1.165-1.603；MM vs.MV/VV，OR = 1.346，95％CI：1.114-1.621）。在等位基因对比，显性和隐性模型中，还发现Met470Val与特发性CP（ICP）风险增加显着相关（M vs. V，OR = 1.298，95％CI：1.020-1.653； MV vs. VV， OR = 1.297，95％CI：1.074-1.566； MM vs. VV，OR = 1.473，95％CI：1.165-1.862； MM vs. MV / VV，OR = 1.254，95％CI：1.023-1.538）。结论：CFTR 470 M等位基因与亚洲和高加索人群的CP风险增加显着相关。CFTR 470 M等位基因也与ICP风险显着相关。MV vs.VV，OR ＝ 1.297，95％CI：1.074-1.566；MM vs.VV，OR = 1.473，95％CI：1.165-1.862；MM vs.MV/VV，OR = 1.254，95％CI：1.023-1.538）。结论：CFTR 470 M等位基因与亚洲和高加索人群的CP风险增加显着相关。CFTR 470 M等位基因也与ICP风险显着相关。MV vs.VV，OR ＝ 1.297，95％CI：1.074-1.566；MM vs.VV，OR = 1.473，95％CI：1.165-1.862；MM vs.MV/VV，OR = 1.254，95％CI：1.023-1.538）。结论：CFTR 470 M等位基因与亚洲和高加索人群的CP风险增加显着相关。CFTR 470 M等位基因也与ICP风险显着相关。
更新日期：2020-01-01
中文翻译：
囊性纤维化跨膜电导调节剂470 Met等位基因与亚洲和白种人人群患慢性胰腺炎的风险增加相关：一项荟萃分析。
背景：据报道，囊性纤维化跨膜电导调节剂（CFTR）蛋白中的Met470Val多态性（1540A> G [rs213950]）与慢性胰腺炎（CP）相关。结果仍然没有定论，因此，我们进行了这项荟萃分析以阐明M470V与CP风险之间的关联。方法/结果：我们对7个病例对照研究进行了荟萃分析，包括来自亚洲和白种人人群的1121名CP患者和2209名对照。我们计算了优势比（OR）和95％置信区间（95％CI）。在所有遗传模型下（M vs.V，OR = 1.260，95％CI：1.134-1.399; MV vs. VV，OR = 1.292，95％CI：1.091），发现Met470Val与CP风险增加显着相关-1.530; MM vs.VV，OR = 1.579，95％CI：1.274-1.956; MV / MV vs.VV，OR = 1.366，95％CI：1.165-1.603；MM vs.MV/VV，OR = 1.346，95％CI：1.114-1.621）。在等位基因对比，显性和隐性模型中，还发现Met470Val与特发性CP（ICP）风险增加显着相关（M vs. V，OR = 1.298，95％CI：1.020-1.653； MV vs. VV， OR = 1.297，95％CI：1.074-1.566； MM vs. VV，OR = 1.473，95％CI：1.165-1.862； MM vs. MV / VV，OR = 1.254，95％CI：1.023-1.538）。结论：CFTR 470 M等位基因与亚洲和高加索人群的CP风险增加显着相关。CFTR 470 M等位基因也与ICP风险显着相关。MV vs.VV，OR ＝ 1.297，95％CI：1.074-1.566；MM vs.VV，OR = 1.473，95％CI：1.165-1.862；MM vs.MV/VV，OR = 1.254，95％CI：1.023-1.538）。结论：CFTR 470 M等位基因与亚洲和高加索人群的CP风险增加显着相关。CFTR 470 M等位基因也与ICP风险显着相关。MV vs.VV，OR ＝ 1.297，95％CI：1.074-1.566；MM vs.VV，OR = 1.473，95％CI：1.165-1.862；MM vs.MV/VV，OR = 1.254，95％CI：1.023-1.538）。结论：CFTR 470 M等位基因与亚洲和高加索人群的CP风险增加显着相关。CFTR 470 M等位基因也与ICP风险显着相关。
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