Macrophages are part of the innate immune system and are present in every organ of the body. They fulfill critical roles in tissue homeostasis and development and are involved in various pathologies. An essential factor for the development, homeostasis, and function of mononuclear phagocytes is the colony stimulating factor-1 receptor (CSF-1R), which has two known ligands: CSF-1 and interleukin-34 (IL-34). While CSF-1 has been extensively studied, the biology and functions of IL-34 are only now beginning to be uncovered. In this review, we discuss recent advances of IL-34 biology in health and disease with a specific focus on mononuclear phagocytes.

中文翻译：

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IL-34 在健康和疾病中的新作用

巨噬细胞是先天免疫系统的一部分，存在于身体的每个器官中。它们在组织稳态和发育中发挥关键作用，并参与各种病理学。单核吞噬细胞发育、稳态和功能的一个重要因素是集落刺激因子 1 受体 (CSF-1R)，它具有两种已知的配体：CSF-1 和白细胞介素 34 (IL-34)。虽然 CSF-1 已被广泛研究，但 IL-34 的生物学和功能现在才刚刚开始被揭示。在这篇综述中，我们讨论了 IL-34 生物学在健康和疾病方面的最新进展，特别关注单核吞噬细胞。