Huntington’s Disease (HD) is an autosomal dominant, progressive neurodegenerative disorder characterized by severe symptoms, including motor impairment, cognitive decline, and psychiatric alterations. Several systems, molecules, and mediators have been associated with the pathophysiology of HD. Among these, there is the Renin-Angiotensin System (RAS), a peptide hormone system that has been associated with the pathology of neuropsychiatric and neurodegenerative disorders. Important alterations in this system have been demonstrated in HD. However, the role of RAS components in HD is still unclear and needs further investigation. Nonetheless, modulation of the RAS components may represent a potential therapeutic strategy for the treatment of HD.

亨廷顿舞蹈病（HD）是常染色体显性遗传，进行性神经退行性疾病，其特征在于严重症状，包括运动障碍，认知能力下降和精神病学改变。几种系统，分子和介体已与HD的病理生理相关。其中，有肾素-血管紧张素系统（RAS），一种肽激素系统，与神经精神病和神经退行性疾病的病理相关。高清显示了该系统的重要变更。但是，RAS组件在高清中的作用仍不清楚，需要进一步研究。但是，RAS成分的调节可能代表了HD的潜在治疗策略。