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Long Noncoding RNAs in Cardiac Development.
Cold Spring Harbor Perspectives in Biology ( IF 7.2 ) Pub Date : 2020-11-01 , DOI: 10.1101/cshperspect.a037374
Michael Alexanian 1 , Samir Ounzain 2
Affiliation  

The exquisite transcriptional control of developmental gene programs is critical for hardwiring the complex expression patterns that govern cell-fate determination and differentiation during heart development. During the past several years, studies have illuminated our understanding of a complex noncoding transcriptional landscape, primarily associated with long noncoding RNAs (lncRNAs), that is implicated in these developmental processes and has begun to reveal key functions of these transcripts. In this review, we discuss the expanding roles for lncRNAs in the earliest points of cardiac development and through differentiation and maturation of multiple cell types within the adult heart. We go on to outline the diverse mechanisms by which cardiovascular lncRNAs orchestrate these transcriptional programs, explore the challenges linked to the study of lncRNAs in developmental phenotypes, and summarize the implications for these molecules in human cardiovascular disorders.

中文翻译:

心脏发育中的长链非编码 RNA。

发育基因程序的精细转录控制对于在心脏发育过程中控制细胞命运决定和分化的复杂表达模式的硬接线至关重要。在过去的几年里,研究阐明了我们对复杂的非编码转录环境的理解,主要与长链非编码 RNA (lncRNA) 相关,它与这些发育过程有关,并开始揭示这些转录物的关键功能。在这篇综述中,我们讨论了 lncRNA 在心脏发育的最早阶段以及成人心脏内多种细胞类型的分化和成熟中的扩展作用。我们继续概述心血管 lncRNA 协调这些转录程序的不同机制,
更新日期:2020-11-03
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