Streptococcus pneumoniae is a major cause of severe invasive disease associated with high mortality and morbidity worldwide. To identify the serotypes most commonly associated with infection in adults in Argentina, 791 pneumococcal isolates from 56 hospitals belonging to 16 provinces and Buenos Aires city were serotyped. The isolates were submitted as part of a National Surveillance Program for invasive pneumococcal disease in adults, which started in 2013. Serotypes 3, 8, 12F, 7F and 1 were the most prevalent among adult patients. During the study period there was no significant difference in serotype distribution between the age groups studied (18–64 and ≥65 years old), except for serotype 1, 3 and 23A. Most prevalent serotypes in pneumonia were serotype 7F, 1, 12F, 8, and 3. When the clinical diagnosis was meningitis, serotype 3 and 12F were the most prevalent, whereas when the diagnosis was sepsis/bacteremia the most prevalent was serotype 8. In this work, for the 18–64-year-old group, PPSV23 and PCV13 serotypes accounted for 74.56% and 44.54% respectively of the cases in the studied period. On the other hand, for the ≥65-year-old group, these serotypes represented 72.30% and 41.42% respectively. The aim of this work was to establish the knowledge bases of the serotypes that cause invasive pneumococcal diseases in the adult population in Argentina and to be able to detect changes in their distribution over time in order to explore the potential serotype coverage of the vaccines in current use.

肺炎链球菌是导致全世界高死亡率和发病率的严重侵袭性疾病的主要原因。为了确定阿根廷最常与成人感染相关的血清型，对来自 16 个省和布宜诺斯艾利斯市的 56 家医院的 791 株肺炎球菌分离株进行了血清型分析。这些分离株是 2013 年开始的成人侵袭性肺炎球菌疾病国家监测计划的一部分。血清型 3、8、12F、7F 和 1 在成人患者中最为普遍。在研究期间，除了血清型 1、3 和 23A 外，所研究年龄组（18-64 岁和 65 岁以上）之间的血清型分布没有显着差异。肺炎中最普遍的血清型是血清型 7F、1、12F、8 和 3。当临床诊断为脑膜炎时，血清型 3 和 12F 最为普遍，而当诊断为败血症/菌血症时，最常见的是血清型 8。 在这项工作中，对于 18-64 岁组，PPSV23 和 PCV13 血清型分别占研究期间病例的 74.56% 和 44.54%。另一方面，对于≥65岁组，这些血清型分别占72.30%和41.42%。这项工作的目的是建立阿根廷成年人群中引起侵袭性肺炎球菌疾病的血清型知识库，并能够检测其分布随时间的变化，以探索当前疫苗的潜在血清型覆盖率。用。分别占研究期间病例的 54%。另一方面，对于≥65岁组，这些血清型分别占72.30%和41.42%。这项工作的目的是建立阿根廷成年人群中引起侵袭性肺炎球菌疾病的血清型知识库，并能够检测其分布随时间的变化，以探索当前疫苗的潜在血清型覆盖率。用。分别占研究期间病例的 54%。另一方面，对于≥65岁组，这些血清型分别占72.30%和41.42%。这项工作的目的是建立阿根廷成年人群中引起侵袭性肺炎球菌疾病的血清型知识库，并能够检测其分布随时间的变化，以探索当前疫苗的潜在血清型覆盖率。用。