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Amphetamine-Dextroamphetamine and Pregnancy: Neonatal Outcomes After Prenatal Prescription Mixed Amphetamine Exposure.
Journal of Attention Disorders ( IF 3 ) Pub Date : 2020-01-13 , DOI: 10.1177/1087054719896857
Sherrill J Rose 1 , Matthew A Hathcock 2 , Wendy M White 2 , Kristi Borowski 2 , Enid Y Rivera-Chiauzzi 2
Affiliation  

Objective: A retrospective cohort study was performed to evaluate whether birthweight was less among infants of women taking amphetamine-dextroamphetamine during pregnancy at our academic institution. Method: We identified mother-infant pairs with documented exposure to amphetamine-dextroamphetamine in pregnancy from 2005 through 2015. Patients were matched 2:1 with unexposed controls. Charts were reviewed for known causes of intrauterine growth restriction. Analysis of birthweight used generalized estimating equation blocking on matching. Medical histories were analyzed with χ2 test or Fisher's exact test. Results: We identified 53 exposed mother-infant pairs. The difference in mean birthweight of infants exposed to amphetamine-dextroamphetamine versus those not exposed was 26.9 g, which is not significant (95% confidence interval [CI] = [-141, 195 g]; p = .75). A significant difference was noted for exposed versus unexposed mothers for comorbid psychiatric illness and history of substance abuse (p < .001). Conclusion: With a limited sample size, our study suggests no significant difference in birthweight.

中文翻译:

苯丙胺-右苯丙胺与妊娠:产前处方混合苯丙胺暴露后的新生儿结局。

目的:进行一项回顾性队列研究,以评估我们学院内在妊娠期间服用苯丙胺-右旋苯丙胺的妇女婴儿的出生体重是否较轻。方法:我们确定了从2005年至2015年怀孕期间苯丙胺-右旋苯丙胺暴露的母婴对。患者与未暴露对照按2:1配对。查看图表以了解宫内生长受限的已知原因。出生体重的分析使用了匹配时的广义估计方程块。用χ2检验或Fisher精确检验对病史进行分析。结果:我们确定了53对暴露的母婴。接触苯丙胺-右旋苯丙胺的婴儿与未接触苯丙胺的婴儿的平均出生体重之差为26.9 g,这并不重要(95%置信区间[CI] = [-141,195 g]; p = 0.75)。对于患有合并症的精神疾病和吸毒史的母亲,暴露的母亲与未暴露的母亲存在显着差异(p <.001)。结论:由于样本量有限,我们的研究表明出生体重没有显着差异。
更新日期:2020-04-20
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