There are no validated, objective diagnostic or prognostic biomarkers for sports-related concussion (SRC), which hinders evidence-based treatment for concussed athletes. While quantitative electrophysiology (EEG) and diffusion tensor imaging (DTI) are promising technologies for providing objective biomarkers for concussion, the degree to which they are related has not been systematically investigated in concussed athletes. This study examined whether diffusion metrics differentiated concussed athletes with prolonged recovery (n = 18) from non-conccused athletes (n = 13) and whether observed diffusion alterations related to EEG. Collegiate athletes (N = 31) completed EEG, neurocognitive, and magnetic resonance imaging. White matter diffusivity differed between the groups in multiple white matter tracts, including the corpus callosum, cingulum bundle, thalamic radiations, and inferior fronto-occipital, inferior longitudinal, and uncinate fasciculi, but not after correction for multiple comparisons. The enhanced Brain Function Index (eBFI), a measure that combines EEG and neurocognitive data, significantly correlated with altered diffusion in the concussed athletes. These preliminary findings suggest that the absolute deviation of diffusion metrics in concussed versus non-concussed athletes may have clinically utility. Results also suggested that the eBFI may be sensitive to early changes from sports-related concussion.

中文翻译：

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白质损伤的扩散张量成像指标与缓慢恢复的脑震荡大学生运动员的基于多模态脑电图的生物标志物相关。

运动相关脑震荡 (SRC) 没有经过验证的、客观的诊断或预后生物标志物，这阻碍了对脑震荡运动员的循证治疗。虽然定量电生理学 (EEG) 和扩散张量成像 (DTI) 是为脑震荡提供客观生物标志物的有前途的技术，但尚未在脑震荡运动员中系统地研究它们的相关程度。这项研究检查了扩散指标是否区分了脑震荡恢复期延长的运动员 ( n  = 18) 和非脑震荡的运动员 ( n  = 13)，以及观察到的扩散改变是否与 EEG 相关。大学生运动员（N = 31) 完成脑电图、神经认知和磁共振成像。白质扩散率在多个白质束中不同，包括胼胝体、扣带束、丘脑辐射和下额枕、下纵束和钩状束，但在多重比较校正后没有差异。增强型脑功能指数 (eBFI) 是一种结合 EEG 和神经认知数据的指标，与脑震荡运动员的扩散改变显着相关。这些初步发现表明，脑震荡与非脑震荡运动员的扩散指标的绝对偏差可能具有临床效用。结果还表明 eBFI 可能对运动相关脑震荡的早期变化敏感。