Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized, among others by abnormal levels of acetyl- and butyrylcholinesterase in the brain. In this study, 47 types of Polish honeys were examined (using colorimetric method) as a source of acetyl- and butyrylcholinesterase inhibitors. The highest potential for AChE inhibition was observed in the case of buckwheat honey (39.51% inhibition), while multi-floral honey showed the highest capacity for BChE inhibition (39.76%). Our study revealed that honeys can be a rich source of cholinesterase inhibitors and therefore may play a role in AD treatment.

中文翻译：

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蜂蜜是阿尔茨海默病胆碱酯酶抑制剂的潜在天然来源

阿尔茨海默病 (AD) 是一种进行性神经退行性疾病，其特征是大脑中乙酰胆碱酯酶和丁酰胆碱酯酶水平异常。在这项研究中，检测了 47 种波兰蜂蜜（使用比色法）作为乙酰胆碱酯酶抑制剂和丁酰胆碱酯酶抑制剂的来源。在荞麦蜂蜜的情况下观察到 AChE 抑制的最高潜力（39.51% 抑制），而多花蜂蜜显示出最高的 BChE 抑制能力（39.76%）。我们的研究表明，蜂蜜是胆碱酯酶抑制剂的丰富来源，因此可能在 AD 治疗中发挥作用。