A humoral immune response in the form of autoantibodies to tumor antigens occurs early during tumor development. Identification of antigens that induce an autoantibody response restricted to a cancer type has the potential to yield markers useful for early detection. A multitude of strategies are currently available for the discovery of tumor antigens directed autoantibodies in circulation. Each approach has advantages and limitations for comprehensive discovery of antigenic epitopes. Herein, we review established and novel strategies and methodologies and highlight potential cancer applications.

中文翻译：

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常见癌症自身抗体签名的开发。

对肿瘤抗原的自身抗体形式的体液免疫应答在肿瘤发展的早期发生。鉴定诱导局限于癌症类型的自身抗体反应的抗原具有产生可用于早期检测的标志物的潜力。当前有许多策略可用于发现循环中肿瘤抗原定向的自身抗体。每种方法都具有全面发现抗原表位的优势和局限性。本文中，我们回顾了既定的和新颖的策略和方法，并重点介绍了潜在的癌症应用。