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Design of photocurable, biodegradable scaffolds for liver lobule regeneration via digital light process-additive manufacturing.
Biofabrication ( IF 9 ) Pub Date : 2020-06-09 , DOI: 10.1088/1758-5090/ab69da
Chia-Lin Teng , June-Yo Chen , Tze-Ling Chang , Syuan-Ku Hsiao , Yi-Kong Hsieh , KaiserAlejandro Villalobos Gorday , Yih-Lin Cheng , Jane Wang

The regeneration of damaged or lost tissue is considered to be a critical step toward realizing full organ regeneration in modern medicine. Although surgical techniques continue to advance, treatment for missing tissues in irregular wounds remains particularly difficult. With increasing interest in the application of additive manufacturing in tissue engineering, the fabrication of customized scaffolds for the regeneration of missing tissue via three-dimensional (3D) printing has become especially promising. Amongst the work on the regeneration of many important organs, liver regeneration is particularly interesting because liver diseases are increasingly prevalent in many countries around the world, resulting in a greater need for liver transplantation. The generation of hexagonal scaffolds for the regeneration of liver lobules is highly demanding, but their 3D structure has been proved difficult to reproduce by traditional fabrication methods. In this work, various hexagonal sc...

中文翻译:

通过数字光工艺增材制造设计用于肝小叶再生的可光固化,可生物降解的支架。

受损或丢失组织的再生被认为是实现现代医学中全器官再生的关键步骤。尽管外科手术技术继续发展,但是治疗不规则伤口中的缺失组织仍然特别困难。随着对增材制造在组织工程中的应用的兴趣日益浓厚,用于通过三维(3D)打印再生缺失组织的定制支架的制造变得特别有希望。在许多重要器官的再生工作中,肝脏再生特别有趣,因为肝脏疾病在世界许多国家/地区越来越普遍,因此对肝脏移植的需求也越来越大。产生用于肝小叶再生的六角形支架的要求很高,但是事实证明,它们的3D结构很难通过传统的制造方法进行复制。在这项工作中,各种六角形的...
更新日期:2020-06-09
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