Abdominal wall defects are associated with abdominal wall surgery, infection and tumour resection. Polypropylene (PP) mesh, which has excellent mechanical strength, is currently the primary clinical repair material. In repairing the abdominal wall, the mesh can erode the bowel and cause other problems. Constructing a barrier that induces a weak inflammatory response and promotes rapid recovery of the peritoneum is important. We used electrospinning technology to construct a silk fibroin coating on the abdominal surface of a PP patch. A rat model was used to compare the inflammatory responses, regeneration of peritoneal tissue, and antiadhesion effects of electrospun regenerated silk fibroin (RSF) coatings, polycaprolactone (PCL) coatings, and noncoated PP meshes. The inflammatory responses, antiadhesion fractions, and areas of RSF and PCL were better than those of PP at 6 weeks. RSF was associated with complete peritoneal regeneration, in contrast to PCL. At 12 weeks, the structure of the PCL peritoneum was unstable, and the adhesion fraction and area were significantly higher than those of RSF. The intact peritoneum could not be effectively regenerated. The RSF group exhibited lower IL-6 levels than the PCL and PP groups but higher VEGF, IL-10 and TGF-β levels, making RSF more conducive to the regeneration of peritoneal and abdominal wall tissues.

中文翻译：

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带有聚丙烯网的再生丝素蛋白（RSF）静电纺丝纤维复合材料，用于在大鼠模型中重建腹壁缺损。

腹壁缺损与腹壁手术，感染和肿瘤切除有关。具有出色机械强度的聚丙烯（PP）筛网目前是主要的临床修复材料。在修复腹壁时，网状物会腐蚀肠腔并引起其他问题。重要的是，建立诱导弱炎症反应并促进腹膜快速恢复的屏障。我们使用静电纺丝技术在PP贴片的腹部表面上构建了丝素蛋白涂层。使用大鼠模型比较电纺再生丝素蛋白（RSF）涂层，聚己内酯（PCL）涂层和未涂层​​PP网格的炎症反应，腹膜组织再生和抗粘连作用。炎症反应，抗粘连分数，6周时，RSF和PCL面积优于PP。与PCL相比，RSF与完全腹膜再生有关。在第12周，PCL腹膜的结构不稳定，并且粘附分数和面积显着高于RSF。完整的腹膜不能有效地再生。RSF组的IL-6水平低于PCL和PP组，但VEGF，IL-10和TGF-β水平较高，这使RSF更有利于腹膜和腹壁组织的再生。