Panic disorder (PD) has been linked to abnormalities in information processing. However, only little evidence has been published for sensory gating in PD. Sensory gating describes the brain’s ability to exclude stimuli of low relevance from higher level information processing, thereby sustaining efficient cognitive processing. Deficits in sensory gating have been associated with various psychiatric conditions, most prominently schizophrenia. In this case-control event-related potential study, we tested 32 patients with PD and 39 healthy controls in a double click paradigm. Both groups were compared with regard to pre-attentive (P50), early-attentive (N100), and late-attentive (P200) sensory gating indices. Contrary to a hypothesized deficit, PD patients and healthy controls showed no differences in P50, N100 and P200 values. These results suggest that sensory gating seems to be functional across the pre-attentive, early-attentive, and late-attentive time span in this clinical population. Given this consistency across auditory sensory gating indices, further research aiming to clarify information processing deficits in PD should focus on other neurophysiological markers to investigate information processing deficits in PD (eg, P300, error-related negativity or mismatch negativity).

中文翻译：

---

恐慌症中的 P50、N100 和 P200 感觉门控

恐慌症 (PD) 与信息处理异常有关。然而，关于 PD 中的感觉门控仅发表了很少的证据。感觉门控描述了大脑从更高级别的信息处理中排除低相关性刺激的能力，从而维持有效的认知处理。感觉门控缺陷与各种精神疾病有关，最突出的是精神分裂症。在此病例对照事件相关电位研究中，我们以双击范例测试了 32 名 PD 患者和 39 名健康对照者。比较两组的前注意 (P50)、早期注意 (N100) 和晚期注意 (P200) 感觉门控指数。与假设的缺陷相反，PD 患者和健康对照组的 P50、N100 和 P200 值没有差异。这些结果表明，感觉门控似乎在这个临床人群的前注意、早期注意和后期注意时间跨度内起作用。鉴于听觉感觉门控指标之间的这种一致性，旨在澄清 PD 中信息处理缺陷的进一步研究应侧重于其他神经生理学标志物，以研究 PD 中的信息处理缺陷（例如，P300、错误相关阴性或错配阴性）。