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The associations of self-rated health with cardiovascular risk proteins: a proteomics approach.
Clinical Proteomics ( IF 3.8 ) Pub Date : 2019-11-18 , DOI: 10.1186/s12014-019-9258-9
Xue Bao 1, 2, 3 , Yan Borné 2 , Songjiang Yin 2, 4 , Kaijun Niu 3 , Marju Orho-Melander 2 , Jan Nilsson 2 , Olle Melander 2 , Gunnar Engström 2
Affiliation  

Background Though subjective, poor self-rated health (SRH) has consistently been shown to predict cardiovascular disease (CVD). The underlying mechanism is unclear. This study evaluates the associations of SRH with biomarkers for CVD, aiming to explore potential pathways between poor SRH and CVD. Methods Based on the Malmö Diet and Cancer Cardiovascular Cohort study, a targeted proteomics approach was used to assess the associations of SRH with 88 cardiovascular risk proteins, measured in plasma from 4521 participants without CVD. The false discovery rate (FDR) was controlled using the Benjamini and Hochberg method. Covariates taken into consideration were age, sex, traditional CVD risk factors (low-density lipoprotein cholesterol, systolic blood pressure, anti-hypertensive medication, diabetes, body mass index, smoking), comorbidity, life-style and psycho-social factors (education level, living alone, alcohol consumption, low physical activity, psychiatric medication, sleep duration, and unemployment). Results Age and sex-adjusted associations with SRH was found for 34 plasma proteins. Nine of them remained significant after adjustments for traditional CVD risk factors. After further adjustment for comorbidity, life-style and psycho-social factors, only leptin (β = - 0.035, corrected p = 0.016) and C-C motif chemokine 20 (CCL20; β = - 0.054, corrected p = 0.016) were significantly associated with SRH. Conclusions Poor SRH was associated with raised concentrations of many plasma proteins. However, the relationships were largely attenuated by adjustments for CVD risk factors, comorbidity and psycho-social factors. Leptin and CCL20 were associated with poor SRH in the present study and could potentially be involved in the SRH-CVD link.

中文翻译:

自评健康与心血管风险蛋白的关联:一种蛋白质组学方法。

背景 尽管主观的、自测健康状况不佳 (SRH) 一直被证明可以预测心血管疾病 (CVD)。潜在机制尚不清楚。本研究评估了 SRH 与 CVD 生物标志物的关联,旨在探索不良 SRH 与 CVD 之间的潜在途径。方法 基于 Malmö 饮食和癌症心血管队列研究,采用靶向蛋白质组学方法评估 SRH 与 88 种心血管风险蛋白的相关性,在 4521 名无 CVD 参与者的血浆中进行测量。使用 Benjamini 和 Hochberg 方法控制错误发现率 (FDR)。考虑的协变量包括年龄、性别、传统 CVD 风险因素(低密度脂蛋白胆固醇、收缩压、抗高血压药物、糖尿病、体重指数、吸烟)、合并症、生活方式和社会心理因素(教育水平、独居、饮酒、低体力活动、精神科药物、睡眠时间和失业)。结果 34 种血浆蛋白发现年龄和性别与 SRH 相关。在对传统的 CVD 风险因素进行调整后,其中九个仍然显着。在对合并症、生活方式和心理社会因素进行进一步调整后,只有瘦素(β = - 0.035,校正 p = 0.016)和 CC 基序趋化因子 20(CCL20;β = - 0.054,校正 p = 0.016)与性健康和生殖健康。结论 较差的 SRH 与许多血浆蛋白浓度升高有关。然而,通过调整 CVD 风险因素、合并症和心理社会因素,这些关系在很大程度上减弱了。
更新日期:2020-04-22
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