Elevated 1‐h plasma glucose (1h‐PG; ≥155 mg/dL) during an oral glucose tolerance test is a risk factor for type 2 diabetes. However, the metabolic characteristics of non‐obese Asians with elevated 1h‐PG are unknown. Thus, we studied 59 non‐obese Japanese men with normal glucose tolerance. We divided study participants into the Low 1h‐PG group (<155 mg/dL) and the High 1h‐PG group (≥155 mg/dL). We compared the metabolic characteristics of the groups, including tissue‐specific insulin sensitivity measured using a two‐step hyperinsulinemic‐euglycemic clamp. Insulinogenic index and adiponectin levels were significantly lower in the High 1h‐PG group than in the Low 1h‐PG group. Other characteristics, including insulin sensitivity, adiposity and ectopic fat accumulation, were similar between the groups. In conclusion, non‐obese Japanese men with high 1h‐PG have impaired early‐phase insulin secretion and lower adiponectin levels. Insulin resistance and abnormal fat distribution were not evident in this population.

中文翻译：

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与非肥胖日本男性 75 克口服葡萄糖耐量试验期间 1 小时血浆葡萄糖水平升高相关的特征。

口服葡萄糖耐量试验期间 1 小时血糖升高（1 小时 PG；≥155 mg/dL）是 2 型糖尿病的危险因素。然而，1h-PG 升高的非肥胖亚洲人的代谢特征尚不清楚。因此，我们研究了 59 名葡萄糖耐量正常的非肥胖日本男性。我们将研究参与者分为低 1h-PG 组（<155 mg/dL）和高 1h-PG 组（≥155 mg/dL）。我们比较了各组的代谢特征，包括使用两步高胰岛素正常血糖钳测量的组织特异性胰岛素敏感性。高 1h-PG 组的胰岛素生成指数和脂联素水平显着低于低 1h-PG 组。其他特征，包括胰岛素敏感性、肥胖和异位脂肪堆积，在各组之间相似。总之，具有高 1h-PG 的非肥胖日本男性早期胰岛素分泌受损，脂联素水平降低。胰岛素抵抗和异常脂肪分布在该人群中不明显。