Metallomics is a rapidly evolving field of bio-metal research that integrates techniques and perspectives from other “-omics” sciences (e.g. genomics, proteomics) and from research vocations further afield. Perhaps the most esoteric of this latter category has been the recent coupling of biomedicine with element and isotope geochemistry, commonly referred to as isotope metallomics. Over the course of less than two decades, isotope metallomics has produced numerous benchmark studies highlighting the use of stable metal isotope distribution in developing disease diagnostics—e.g. cancer, neurodegeneration, osteoporosis—as well as their utility in deciphering the underlying mechanisms of such diseases. These pioneering works indicate an enormous wealth of potential and provide a call to action for researchers to combine and leverage expertise and resources to create a clear and meaningful path forward. Doing so with efficacy and impact will require not only building on existing research, but also broadening collaborative networks, bolstering and deepening cross-disciplinary channels, and establishing unified and realizable objectives. The aim of this review is to briefly summarize the field and its underpinnings, provide a directory of the state of the art, outline the most encouraging paths forward, including their limitations, outlook and speculative upcoming breakthroughs, and finally to offer a vision of how to cultivate isotope metallomics for an impactful future.

金属组学是一个快速发展的生物金属研究领域，它融合了其他“组学”科学（例如基因组学，蛋白质组学）以及更远的研究领域的技术和观点。后一类中最深奥的也许是生物医学与元素和同位素地球化学的最新结合，通常被称为同位素金属组学。在不到二十年的时间里，同位素金属学已经开展了许多基准研究，突出了稳定的金属同位素分布在发展疾病诊断（例如癌症，神经退行性疾病，骨质疏松症）中的用途，以及它们在解释此类疾病的潜在机制中的效用。这些开拓性的作品表明了巨大的潜力，并呼吁研究人员结合并利用专业知识和资源，以创造清晰而有意义的前进之路。要发挥效力和影响，不仅需要建立在现有研究的基础上，而且还需要扩大协作网络，加强和深化跨学科渠道以及建立统一和可实现的目标。这篇综述的目的是简要概述该领域及其基础，提供最新技术目录，概述最令人鼓舞的前进方向，包括其局限性，前景和即将到来的投机性突破，并最终就如何培育同位素冶金学，以实现具有影响力的未来。要发挥效力和影响，不仅需要建立在现有研究的基础上，而且还需要扩大协作网络，加强和深化跨学科渠道以及建立统一和可实现的目标。这篇综述的目的是简要概述该领域及其基础，提供最新技术目录，概述最令人鼓舞的前进方向，包括其局限性，前景和即将到来的投机性突破，并最终就如何培育同位素冶金学，以实现具有影响力的未来。要发挥效力和影响，不仅需要建立在现有研究的基础上，而且还需要扩大协作网络，加强和深化跨学科渠道以及建立统一和可实现的目标。这篇综述的目的是简要概述该领域及其基础，提供最新技术目录，概述最令人鼓舞的前进方向，包括其局限性，前景和即将到来的投机性突破，并最终就如何培育同位素冶金学，以实现具有影响力的未来。