Abstract

Electrospinning as method for fabrication of wound dressing materials with included medical plant extracts for wound treatment has lately gained increasing attention. However, the transfer of nanofiber fabrication with included plant extracts from the research to the pilot and industrial scale production, using needleless electrospinning is a vital area of research, which could enable its large-scale commercial exploitation. Carboxymethyl cellulose (CMC) is a cheap, water soluble biopolymer, and in blends with the spinning agent polyethylene oxide (PEO) it is a suitable polymer for a large-scale nanofiber production. Thus, this study addresses the needleless electrospinning of CMC/PEO/plant extract blend aqueous solutions in order to fabricate cellulose based wound dressing material, suitable for treatment of acute wounds. The influence of plant extracts on the morphology of the electrospun mats was further evaluated. The antioxidant and antibacterial properties of the as-prepared electrospun mats were determined, where special attention was devoted to the stability/degradation study of phenolic compounds in plant extracts during the electrospinning process. This research was complemented by the release study and cell viability testing with results indicating a promising potential of this product to use for wound care as a self-contained wound dressing or as a part of number of already existing novel wound dressing materials.

Graphic abstract

摘要

电纺丝作为具有包括用于伤口处理的药用植物提取物的伤口敷料材料的制造方法，近来受到越来越多的关注。然而，使用无针静电纺丝技术将包括研究中的植物提取物在内的纳米纤维制造转移到中试和工业规模生产中，是至关重要的研究领域，这可以使其大规模商业开发。羧甲基纤维素（CMC）是一种廉价的水溶性生物聚合物，与纺丝剂聚环氧乙烷（PEO）掺混时，它是适合大规模纳米纤维生产的聚合物。因此，本研究致力于CMC / PEO /植物提取物共混物水溶液的无针静电纺丝，以制造适用于急性伤口的纤维素基伤口敷料。进一步评估了植物提取物对电纺垫形态的影响。测定了所制备的电纺垫的抗氧化和抗菌性能，其中特别关注了静电纺丝过程中植物提取物中酚类化合物的稳定性/降解研究。该研究得到释放研究和细胞活力测试的补充，结果表明该产品作为独立的伤口敷料或许多现有新型伤口敷料的一部分，有望用于伤口护理。其中特别关注了静电纺丝过程中植物提取物中酚类化合物的稳定性/降解研究。该研究得到释放研究和细胞活力测试的补充，结果表明该产品作为独立的伤口敷料或许多现有新型伤口敷料的一部分，有望用于伤口护理。其中特别关注了静电纺丝过程中植物提取物中酚类化合物的稳定性/降解研究。该研究得到释放研究和细胞存活力测试的补充，结果表明该产品作为独立的伤口敷料或许多现有新型伤口敷料的一部分，有望用于伤口护理。

图形摘要