An N-heterocyclic carbene (NHC)-catalyzed direct deuteration of aldehydes in a mixed solvent of deuterium oxide (D2O) and cyclopentyl methyl ether was established. The present deuteration is possibly initiated by the formation of a Breslow intermediate from the aldehyde and the NHC, with subsequent trapping by D2O providing the monodeuterated aldehyde.

中文翻译：

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N-杂环卡宾催化 D2O 中醛的氘化

建立了 N-杂环卡宾 (NHC) 催化的醛在氧化氘 (D2O) 和环戊基甲基醚的混合溶剂中的直接氘化。目前的氘化可能是由醛和 NHC 形成 Breslow 中间体引发的，随后被 D2O 捕获，提供单氘化醛。