Homogeneous transition metal catalysts allow for high selectivity at mild reaction conditions. However, very high recoveries of the precious catalyst are decisive for the development of economic processes, especially in case of reactions with an atom economy below 100% since co-products and their potential accumulation have to be considered. To address this issue, an innovative process concept is investigated, which exploits thermomorphic multiphase systems combined with organic solvent nanofiltration for homogeneous catalyst recovery and co-product removal. In this concept, the reaction takes place at elevated temperature in a homogeneous liquid phase, while the reactor effluent is cooled down, inducing a phase split. This allows for the separation of a product-rich non-polar and a catalyst-rich polar phase that is recycled into the reactor. The current article investigates this concept considering a reductive amination reaction as case study based on an experimental membrane screening and a model-based evaluation. DuraMem 150 (T1) proved to be the best membrane for all tested solvents as catalyst ligand rejections higher than 99% and a removal of the co-product water were achieved. The model-based evaluation indicated a final OSN-process of three stages for the solvent methanol and the requirement of a subsequent solvent recovery that is realized by distillation.

均相过渡金属催化剂可在温和的反应条件下实现高选择性。但是，珍贵催化剂的很高回收率对经济方法的发展具有决定性作用，特别是在原子经济低于100％的反应情况下，因为必须考虑副产物及其潜在的积累。为了解决这个问题，研究了一种创新的工艺概念，该工艺利用热定型多相系统与有机溶剂纳米过滤相结合来回收均相催化剂和去除副产物。在这个概念中，反应在高温下在均相液相中进行，而反应器流出物被冷却，引起相分离。这允许分离富含产物的非极性相和富含催化剂的极性相，将其再循环到反应器中。本文基于实验性的膜筛选和基于模型的评估，以还原胺化反应为案例研究了这一概念。DuraMem 150（T1）被证明是所有测试溶剂的最佳膜，因为催化剂配体的截留率高于99％，并且去除了副产物水。基于模型的评估表明，溶剂甲醇分为三个阶段的最终OSN工艺，并且需要通过蒸馏实现后续溶剂回收。DuraMem 150（T1）被证明是所有测试溶剂的最佳膜，因为催化剂配体的截留率高于99％，并且去除了副产物水。基于模型的评估表明，溶剂甲醇分为三个阶段的最终OSN工艺，并且需要通过蒸馏实现后续溶剂回收。DuraMem 150（T1）被证明是所有测试溶剂的最佳膜，因为催化剂配体的截留率高于99％，并且去除了副产物水。基于模型的评估表明，溶剂甲醇分为三个阶段的最终OSN工艺，并且需要通过蒸馏实现后续溶剂回收。