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Compositional analysis of the associations between 24-h movement behaviours and cardio-metabolic risk factors in overweight and obese adults with pre-diabetes from the PREVIEW study: cross-sectional baseline analysis.
International Journal of Behavioral Nutrition and Physical Activity ( IF 8.7 ) Pub Date : 2020-03-04 , DOI: 10.1186/s12966-020-00936-5
Nils Swindell 1 , Paul Rees 1 , Mikael Fogelholm 2 , Mathijs Drummen 3 , Ian MacDonald 4 , J Alfredo Martinez 5, 6, 7, 8 , Santiago Navas-Carretero 5, 6, 7 , Teodora Handjieva-Darlenska 9 , Nadka Boyadjieva 9 , Georgi Bogdanov 9 , Sally D Poppitt 10 , Nicholas Gant 10 , Marta P Silvestre 10 , Jennie Brand-Miller 11 , Wolfgang Schlicht 12 , Roslyn Muirhead 11 , Shannon Brodie 11 , Heikki Tikkanen 13 , Elli Jalo 2 , Margriet Westerterp-Plantenga 3 , Tanja Adam 3 , Pia Siig Vestentoft 14 , Thomas M Larsen 14 , Anne Raben 14 , Gareth Stratton 1
Affiliation  

Physical activity, sedentary time and sleep have been shown to be associated with cardio-metabolic health. However, these associations are typically studied in isolation or without accounting for the effect of all movement behaviours and the constrained nature of data that comprise a finite whole such as a 24 h day. The aim of this study was to examine the associations between the composition of daily movement behaviours (including sleep, sedentary time (ST), light intensity physical activity (LIPA) and moderate-to-vigorous activity (MVPA)) and cardio-metabolic health, in a cross-sectional analysis of adults with pre-diabetes. Further, we quantified the predicted differences following reallocation of time between behaviours. Accelerometers were used to quantify daily movement behaviours in 1462 adults from eight countries with a body mass index (BMI) ≥25 kg·m− 2, impaired fasting glucose (IFG; 5.6–6.9 mmol·l− 1) and/or impaired glucose tolerance (IGT; 7.8–11.0 mmol•l− 1 2 h following oral glucose tolerance test, OGTT). Compositional isotemporal substitution was used to estimate the association of reallocating time between behaviours. Replacing MVPA with any other behaviour around the mean composition was associated with a poorer cardio-metabolic risk profile. Conversely, when MVPA was increased, the relationships with cardiometabolic risk markers was favourable but with smaller predicted changes than when MVPA was replaced. Further, substituting ST with LIPA predicted improvements in cardio-metabolic risk markers, most notably insulin and HOMA-IR. This is the first study to use compositional analysis of the 24 h movement composition in adults with overweight/obesity and pre-diabetes. These findings build on previous literature that suggest replacing ST with LIPA may produce metabolic benefits that contribute to the prevention and management of type 2 diabetes. Furthermore, the asymmetry in the predicted change in risk markers following the reallocation of time to/from MVPA highlights the importance of maintaining existing levels of MVPA. ClinicalTrials.gov (NCT01777893).

中文翻译:

PREVIEW研究中超重和肥胖成人糖尿病患者的24小时运动行为与心血管代谢危险因素之间的关联组成分析:横断面基线分析。

身体活动,久坐时间和睡眠与心脏代谢健康有关。但是,通常对这些关联进行孤立研究,或者不考虑所有运动行为的影响以及构成有限整体(例如24小时)的数据的约束性质。这项研究的目的是检查日常运动行为(包括睡眠,久坐时间(ST),光强度体育锻炼(LIPA)和中度至剧烈运动(MVPA))的组成与心脏代谢健康之间的关联。在对患有糖尿病前期成人的横断面分析中 此外,我们量化了行为之间时间重新分配后的预测差异。加速度计用于量化八个国家体重指数(BMI)≥25kg·m−2,空腹血糖(IFG; 5.6–6.9mmol·l-1)和/或血糖受损的1462名成年人的日常运动行为耐受性(IGT;口服葡萄糖耐量试验后2小时,7.8-11.0 mmol•l-1-OGTT)。等时组成置换用于估计行为之间重新分配时间的关联。用围绕平均成分的任何其他行为代替MVPA与较差的心血管代谢风险相关。相反,当MVPA增加时,与心脏代谢风险标志物的关系是有利的,但与更换MVPA相比,其预测变化较小。此外,用LIPA替代ST可以预测心脏代谢风险指标(尤其是胰岛素和HOMA-IR)的改善。这是首次对超重/肥胖和糖尿病前期成年人24小时运动成分进行成分分析的研究。这些发现建立在以前的文献上,这些文献表明用LIPA替代ST可能产生有助于预防和控制2型糖尿病的代谢益处。此外,在将时间重新分配到MVPA或从MVPA重新分配时间之后,风险标记的预测变化中的不对称性凸显了维持现有MVPA水平的重要性。ClinicalTrials.gov(NCT01777893)。在将时间重新分配到MVPA或从MVPA重新分配时间之后,风险标记的预测变化中的不对称性凸显了维持现有MVPA水平的重要性。ClinicalTrials.gov(NCT01777893)。在将时间重新分配到MVPA或从MVPA重新分配时间之后,风险标记的预测变化的不对称性凸显了维持现有MVPA水平的重要性。ClinicalTrials.gov(NCT01777893)。
更新日期:2020-04-22
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