Many studies have related biochemical characteristics to violence and have reported schizophrenia could elevated the risk of violent behaviour. However, the metabolic characteristics of schizophrenia patients with violence (V.SC) are unclear. To explore the metabolic characteristics of schizophrenia with violence and to identify potential biomarkers, untargeted metabolomics was performed by using gas chromatography time-of-flight mass spectrometry to analyse the plasma metabolites of fifty-three V.SC and twenty-four schizophrenia patients without violence (NV.SC). Multivariate and univariate analyses were performed to identify differential metabolites and biomarkers. Violence was assessed by the MacArthur Violence Assessment Study method. Psychiatric symptoms were assessed by the Positive and Negative Syndrome Scale. Multivariate analysis was unable to distinguish V.SC from NV.SC. Glycerolipid metabolism and phenylalanine, tyrosine and tryptophan biosynthesis were the differential metabolic pathways between V.SC and NV.SC. We confirmed ten metabolites and five metabolites as metabolic biomarkers of V.SC by random forest and support vector machine analysis, respectively. The biomarker panel, including the ratio of L-asparagine to L-aspartic acid, vanillylmandelic acid and glutaric acid, yielded an area under the receiver operating characteristic curve of 0.808. This study gives a holistic view of the metabolic phenotype of schizophrenia with violence which is characterized by the dysregulation of lipids and amino acids. These results might provide information for the aetiological understanding and management of violence in schizophrenia; however, this is a preliminary metabolomics study about schizophrenia with violence, which needs to be repeated in future studies.

中文翻译：

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暴力性精神分裂症患者的氨基酸和脂质代谢失调。

许多研究将生物化学特征与暴力相关，并报告了精神分裂症可能会增加暴力行为的风险。但是，尚不清楚暴力性精神分裂症患者的代谢特征（V.SC）。为了探索暴力精神分裂症的代谢特征并鉴定潜在的生物标志物，通过使用气相色谱飞行时间质谱法分析了53例V.SC和24例无暴力精神分裂症患者的血浆代谢物，进行了非靶向代谢组学。 （NV.SC）。进行多变量和单变量分析以鉴定差异代谢物和生物标志物。暴力是通过MacArthur暴力评估研究方法评估的。精神症状通过阳性和阴性综合征量表进行评估。多变量分析无法区分V.SC和NV.SC。甘油脂代谢和苯丙氨酸，酪氨酸和色氨酸的生物合成是V.SC和NV.SC之间的差异代谢途径。我们通过随机森林和支持向量机分析分别确认了10种代谢物和5种代谢物作为V.SC的代谢生物标记。生物标志物组，包括L-天冬酰胺与L-天冬氨酸，香草戊二酸和戊二酸的比率，在接收器工作特性曲线下产生的面积为0.808。这项研究提供了以精神分裂症伴有暴力行为的代谢表型的整体观点，其特征在于脂质和氨基酸的失调。这些结果可能为精神分裂症的暴力的病因学理解和处理提供信息。然而，