Background and Purpose- In previous studies, isolated nonspecific ST-segment and T-wave abnormalities (NSSTTAs), a common finding on ECGs, were associated with greater risk for incident coronary artery disease. Their association with incident stroke remains unclear. Methods- The REGARDS (Reasons for Geographic and Racial Differences in Stroke) study is a population-based, longitudinal study of 30 239 white and black adults enrolled from 2003 to 2007 in the United States. NSSTTAs were defined from baseline ECG using the standards of Minnesota ECG Classification (Minnesota codes 4-3, 4-4, 5-3, or 5-4). Participants with prior stroke, coronary heart disease, and major and minor ECG abnormalities other than NSSTTAs were excluded from analysis. Multivariable Cox proportional hazards regression was used to examine calculate hazard ratios of incident ischemic stroke by presence of baseline NSSTTAs. Results- Among 14 077 participants, 3111 (22.1%) had NSSTTAs at baseline. With a median of 9.6 years follow-up, 106 (3.4%) with NSSTTAs had ischemic stroke compared with 258 (2.4%) without NSSTTAs. The age-adjusted incidence rates (per 1000 person-years) of stroke were 2.93 in those with NSSTTAs and 2.19 in those without them. Adjusting for baseline age, sex, race, geographic location, and education level, isolated NSSTTAs were associated with a 32% higher risk of ischemic stroke (hazard ratio, 1.32 [95% CI, 1.05-1.67]). With additional adjustment for stroke risk factors, the risk of stroke was increased 27% (hazard ratio, 1.27 [95% CI, 1.00-1.62]) and did not differ by age, race, or sex. Conclusions- Presence of NSSTTAs in persons with an otherwise normal ECG was associated with a 27% increased risk of future ischemic stroke.

中文翻译：

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在REGARDS研究中，心电图ST-T异常与中风风险相关。

背景和目的-在以前的研究中，孤立的非特异性ST段和T波异常（NSSTTA）是ECG的常见发现，与发生冠状动脉疾病的风险较高相关。它们与中风的关联尚不清楚。方法-REGARDS（卒中地理和种族差异的原因）研究是一项基于人群的纵向研究，研究对象是2003年至2007年在美国招募的30239名白人和黑人。使用明尼苏达州ECG分类标准（明尼苏达州代码4-3、4-4、5-3或5-4）从基线ECG定义NSSTTA。分析中排除了患有中风，冠心病以及非NSSTTA的主要和次要心电图异常的参与者。使用多变量Cox比例风险回归来检查基线NSSTTA的存在对缺血性卒中的危险比。结果-在14077名参与者中，有3111名（22.1％）在基线时患有NSSTTA。中位随访9.6年，有NSSTTA的缺血性卒中为106例（3.4％），而没有NSSTTA的为258例（2.4％）。患有NSSTTA的患者的年龄调整后的中风发生率（每1000人年）为2.93，而没有NSSTTA的患者为2.19。调整基线年龄，性别，种族，地理位置和教育水平，孤立的NSSTTA与缺血性中风的危险性增加32％（危险比，1.32 [95％CI，1.05-1.67]）。通过对中风危险因素进行额外调整，中风风险增加了27％（危险比，1.27 [95％CI，1.00-1.62]），并且没有年龄，种族或性别的差异。