Cell adhesion acts as a complex process that is hardly promoted through surfaces with a single performance. Controlling the cell's adhesion on the interfaces between the synthetic materials and the biological environments remains a real challenge in the biomedical fields. Herein, based on RGD peptide modified carboxymethyl chitosan (CCS‐R) and dopamine modified oxidized alginate (OALG‐D), a layer‐by‐layer (LbL) self‐assemble multilayered (CCS‐R/OALG‐D)₁₅ film is developed. The multifunctional (CCS‐R/OALG‐D)₁₅ film with a self‐healing, highly adherent, biocompatible, and antioxidative biomatrix property for the cell adhesion is fabricated with the Schiff‐base bond, electrovalent bond, and hydrogen bond. The LbL multilayered film exhibits the significant cell adhesion ability for the normal human dermal fibroblast cells and the coral Acropopa formosa cells. Furthermore, it holds high self‐healing efficiency (88.8%), excellent adhesion strength (adhesive stress: 61.1 MPa), and outstanding antioxidation (free radical scavenging rate: 86.8%). Furthermore, it is demonstrated that the LbL multifunctional film, as a culture matrix, has prolonged the survival of the coral Acropopa formosa. Therefore, the incorporation of a self‐healing, high adhesion, superior cell adhesion, and antioxidation property into a single LbL self‐assembly film provides a promising platform for regenerative medicine.

中文翻译：

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自修复，高附着力和抗氧化的LbL多层膜可增强细胞粘附力

细胞粘附是一个复杂的过程，几乎无法通过单一性能促进表面粘附。在生物医学领域中，控制细胞在合成材料和生物环境之间的界面上的粘附仍然是一个真正的挑战。在此，基于RGD肽修饰的羧甲基壳聚糖（CCS‐R）和多巴胺修饰的氧化藻酸盐（OALG‐D），形成了一层一层（LbL）自组装多层（CCS‐R / OALG‐D）₁₅膜发达。多功能（CCS‐R / OALG‐D）₁₅具有席夫碱键，电价键和氢键的具有自愈性，高粘附性，生物相容性和抗氧化生物基质特性的细胞粘附膜可用于细胞粘附。LbL多层膜对正常人的真皮成纤维细胞和珊瑚Acropopa formosa细胞具有显着的细胞粘附能力。此外，它具有很高的自修复效率（88.8％），出色的粘合强度（粘合应力：61.1 MPa）和出色的抗氧化性（自由基清除率：86.8％）。此外，还证明了LbL多功能薄膜作为一种培养基质可以延长福尔摩斯珊瑚的存活。。因此，将自我修复，高粘附力，优异的细胞粘附力和抗氧化性能整合到单个LbL自组装膜中，为再生医学提供了有希望的平台。