A deep partial thickness (DPT) burn injury refers to burn damage involving the epidermis and major dermis, whose prognosis depends greatly on wound management. Lack of effective management can lead to an elongated healing process and aggravated scar formation, which can severely disturb patients, both physically and mentally. A dressing with good water absorption and moderate mechanical properties is crucial for healing promotion, and the prevention of scar formation is highly desirable. In this project, a hyaluronic acid combined lyotropic liquid crystal based spray dressing (HLCSD) loaded with the anti-fibrotic drug pirfenidone (PFD) has been designed. HLCSD is expected to achieve the goals of both wound healing promotion and scar prophylaxis. Its water absorption capacity, mechanical properties, drug release behavior and phase transition are fully evaluated. HLCSD possesses low viscosity for spray administration and high levels of water absorption for exudate absorption. An in situ gel composed of self-assembled lattice nanostructures provides excellent mechanical protection to promote the healing process and steady PFD release to exert a scar prophylaxis effect. The benefit of HLCSD on the wound healing rate is verified in vivo. In the DPT burn wound model we established, HLCSD also exhibits excellent healing promotion effects, and PFD-loaded HLCSD shows scar prophylaxis effects and displays an ideal prognosis, with skin as smooth as healthy skin. The healing promotion of HLCSD is considered to be related to the alleviation of inflammation, with an obviously shortened inflammation phase, with contributions from water management, mechanical protection and anti-inflammation by HLCSD. The scar prophylaxis of PFD-loaded HLCSD is proven to be related to the regulation of collagen synthesis and degradation, involving key cytokines like TGF-β and MMP-1. Taken together, the PFD-loaded HLCSD with healing promotion and scar prophylaxis offers significant promise as a spray dressing for DPT burn injuries.

中文翻译：

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基于溶致液晶的吡非尼酮负载的喷涂敷料，用于深层局部烧伤治疗：促进愈合和预防疤痕

深部局部厚度烧伤是指涉及表皮和主要真皮的烧伤，其预后很大程度上取决于伤口的处理。缺乏有效的管理会导致愈合过程延长和疤痕形成加剧，从而严重影响患者的身心健康。具有良好吸水率和适度机械性能的敷料对促进愈合至关重要，因此非常需要防止疤痕形成。在该项目中，已设计了负载有抗纤维化药物吡非尼酮（PFD）的透明质酸组合溶致液晶基喷雾敷料（HLCSD）。HLCSD有望实现促进伤口愈合和预防疤痕的目标。其吸水能力，机械性能，充分评估了药物释放行为和相变。HLCSD具有较低的喷雾剂粘度和较高的吸水率以吸收渗出液。一个由自组装晶格纳米结构组成的原位凝胶可提供出色的机械保护，促进愈合过程，并稳定释放PFD，从而起到预防疤痕的作用。HLCSD对伤口愈合率的益处已在体内得到证实。在我们建立的DPT烧伤创面模型中，HLCSD还具有出色的促进愈合作用，而载有PFD的HLCSD可以预防疤痕并显示理想的预后，使皮肤像健康皮肤一样光滑。HLCSD的促进愈合被认为与炎症减轻有关，炎症阶段明显缩短，这归因于HLCSD的水管理，机械保护和抗炎作用。事实证明，PFD加载的HLCSD的瘢痕预防与胶原合成和降解的调节有关，涉及关键的细胞因子如TGF-β和MMP-1。总而言之，载有PFD的HLCSD具有促进愈合和预防疤痕的功能，有望作为DPT烧伤的喷剂。