Obesity begets obesity, diabetes begets diabetes. This vicious cycle needs to be interrupted if the obesity and diabetes epidemic are to be combatted. Pregnancies in mothers with obesity or pregnancies complicated by gestational diabetes often result in a neonate with a high birthweight. The neonatal phenotype in these pregnancies is characterised by increased fat accretion, whereas lean body mass is unaltered. ^,  Importantly, it is not only neonates who have a high birthweight (ie, large-for-gestational age) that have increased adiposity, but even neonates with an inconspicuous birthweight (ie, within the normal range) have more fat compared with neonates born from mothers without obesity or gestational diabetes. Neonatal fat, but not birthweight, is associated with childhood obesity. When children with obesity grow up and have obesity when they enter their own pregnancy, their offspring again carry the higher risk for being born with excess fat. Thus, reducing neonatal adiposity must be one of the aims of public health efforts to interrupt the vicious cycle of obesity.

中文翻译：

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子宫内脂肪的增长：时间就是一切。

肥胖导致肥胖，糖尿病导致糖尿病。如果要对抗肥胖症和糖尿病流行病，就必须中断这种恶性循环。肥胖母亲的妊娠或妊娠合并妊娠糖尿病的母亲通常会导致新生儿体重较高。这些妊娠的新生儿表型的特征是脂肪增加，而瘦体重不变。^， 重要的是，不仅肥胖的新生儿体重增加（即，胎龄大）肥胖，而且出生体重不明显的新生儿（即，在正常范围内）与出生于新生儿的新生儿相比，脂肪也更多。没有肥胖或妊娠糖尿病的母亲。新生儿脂肪，而不是体重，与儿童肥胖有关。当肥胖儿童长大并在怀孕后又肥胖时，他们的后代又会面临出生时脂肪过多的更高风险。因此，减少新生儿肥胖症必须成为公共卫生工作的目标之一，以打断肥胖的恶性循环。