Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a highly debilitating disease with heterogeneous constitutional and neurological complaints. Infection-like symptoms often herald disease onset, but no pathogen or immune defect has been conclusively linked. In this issue of the JCI, Mandarano et al. illuminate bioenergetic derangements of ME/CFS T cell subsets. CD4+ and CD8+ T cells had impaired resting glycolysis. CD8+ cells additionally showed activation-related metabolic remodeling deficits and decreased mitochondrial membrane potential; a subset had increased resting mitochondrial mass. Immune senescence and exhaustion paradigms offer only partial explanations. Hence, unique mechanisms of disrupted immunometabolism may underlie the complex neuroimmune dysfunction of ME/CFS.

中文翻译：

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免疫代谢的光能穿透“脑雾”吗？

肌病性脑脊髓炎/慢性疲劳综合症（ME / CFS）是一种高度虚弱的疾病，具有不同的体质和神经系统不适。感染样症状通常预示着疾病的发作，但是没有确凿地联系到病原体或免疫缺陷。在本期JCI中，Mandarano等人。阐明了ME / CFS T细胞亚群的生物能紊乱。CD4 +和CD8 + T细胞损害了静息糖酵解。CD8 +细胞还表现出与激活有关的代谢重塑缺陷和线粒体膜电位降低。一个子集增加了静息线粒体质量。免疫衰老和力竭范例仅提供部分解释。因此，破坏免疫代谢的独特机制可能是ME / CFS复杂的神经免疫功能障碍的基础。