Red meat, poultry and fish consumption and risk of diabetes: a 9 year prospective cohort study of the China Kadoorie Biobank.,Diabetologia

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Red meat, poultry and fish consumption and risk of diabetes: a 9 year prospective cohort study of the China Kadoorie Biobank.
Diabetologia ( IF 8.2 ) Pub Date : 2020-01-22 , DOI: 10.1007/s00125-020-05091-x
Huaidong Du _{1,

2} , Yu Guo ₃ , Derrick A Bennett ₂ , Fiona Bragg ₂ , Zheng Bian ₃ , Mahmuda Chadni ₂ , Canqing Yu ₄ , Yiping Chen _{1,

2} , Yunlong Tan ₃ , Iona Y Millwood _{1,

2} , Wei Gan ₅ , Ling Yang _{1,

2} , Pang Yao ₂ , Guojin Luo ₆ , Jianguo Li ₆ , Yulu Qin ₇ , Jun Lv ₄ , Xu Lin ₈ , Tim Key ₉ , Junshi Chen ₁₀ , Robert Clarke ₂ , Liming Li ₄ , Zhengming Chen ₂ ,

Affiliation

Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK.
Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, OX3 7LF, UK.
Chinese Academy of Medical Sciences, no. 9 Dong Dan San Tiao, Dong Cheng District, Beijing, 100730, China.
Department of Epidemiology and Biostatistics, Peking University Health Science Center, Peking University, Beijing, China.
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Pengzhou CDC, Chengdu, Sichuan Province, China.
NCDs Prevention and Control Department, Liuzhou CDC, Guangxi Autonomous Zone, China.
CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China.
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
China National Center for Food Safety Risk Assessment, Beijing, China.

AIMS/HYPOTHESIS Previous evidence linking red meat consumption with diabetes risk mainly came from western countries, with little evidence from China, where patterns of meat consumption are different. Moreover, global evidence remains inconclusive about the associations of poultry and fish consumption with diabetes. Therefore we investigated the associations of red meat, poultry and fish intake with incidence of diabetes in a Chinese population. METHODS The prospective China Kadoorie Biobank recruited ~512,000 adults (59% women, mean age 51 years) from ten rural and urban areas across China in 2004-2008. At the baseline survey, a validated interviewer-administered laptop-based questionnaire was used to collect information on the consumption frequency of major food groups including red meat, poultry, fish, fresh fruit and several others. During ~9 years of follow-up, 14,931 incidences of new-onset diabetes were recorded among 461,036 participants who had no prior diabetes, cardiovascular diseases or cancer at baseline. Cox regression analyses were performed to calculate adjusted HRs for incident diabetes associated with red meat, poultry and fish intake. RESULTS At baseline, 47.0%, 1.3% and 8.9% of participants reported a regular consumption (i.e. ≥4 days/week) of red meat, poultry and fish, respectively. After adjusting for adiposity and other potential confounders, each 50 g/day increase in red meat and fish intake was associated with 11% (HR 1.11 [95% CI 1.04, 1.20]) and 6% (HR 1.06 [95% CI 1.00, 1.13]) higher risk of incident diabetes, respectively. For both, the associations were more pronounced among men and women from urban areas, with an HR (95% CI) of 1.42 (1.15, 1.74) and 1.18 (1.03, 1.36), respectively, per 50 g/day red meat intake and 1.15 (1.02, 1.30) and 1.11 (1.01, 1.23), respectively, per 50 g/day fish intake. There was no significant association between diabetes and poultry intake, either overall (HR 0.96 [95% CI 0.83, 1.12] per 50 g/day intake) or in specific population subgroups. CONCLUSIONS/INTERPRETATION In Chinese adults, both red meat and fish, but not poultry, intake were positively associated with diabetes risk, particularly among urban participants. Our findings add new evidence linking red meat and fish intake with cardiometabolic diseases. DATA AVAILABILITY Details of how to access the China Kadoorie Biobank data and rules of China Kadoorie Biobank data release are available from www.ckbiobank.org/site/Data+Access.

更新日期：2020-03-03

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