Keratins derived from human hair have been suggested to be particularly effective in general surgical wound healing. However, the healing of a combined radiation-wound injury is a multifaceted regenerative process. Here, hydrogels fabricated with human hair keratins were used to test the wound healing effects on rats suffering from combined radiation-wound injuries. Briefly, the keratin extracts were verified by dodecyl sulfate polyacrylamide gel electrophoresis analysis and amino acid analysis, and the keratin hydrogels were then characterized by morphological observation, Fourier transform infrared spectroscopy analysis and rheology analyses. The results of the cell viability assay indicated that the keratin hydrogels could enhance cell growth after radiation exposure. Furthermore, keratin hydrogels could accelerate wound repair and improve the survival rate in vivo. The results demonstrate that keratin hydrogels possess a strong ability to accelerate the repair of a combined radiation-wound injury, which opens up new tissue regeneration applications for keratins.

中文翻译：

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头发角蛋白可促进放射伤合并大鼠的伤口愈合。

已经提出，源自人发的角蛋白在一般的外科伤口愈合中特别有效。然而，放射线伤合并的愈合是多方面的再生过程。在这里，用人发角蛋白制成的水凝胶用于测试对遭受放射线伤害的大鼠的伤口愈合效果。简而言之，通过十二烷基硫酸盐聚丙烯酰胺凝胶电泳分析和氨基酸分析对角蛋白提取物进行验证，然后通过形态学观察，傅立叶变换红外光谱分析和流变分析对角蛋白水凝胶进行表征。细胞活力测定的结果表明，角蛋白水凝胶可以增强辐射照射后的细胞生长。此外，角蛋白水凝胶可加速伤口修复并提高体内存活率。结果表明，角蛋白水凝胶具有很强的加速复合放射伤损伤修复的能力，这为角蛋白开辟了新的组织再生应用。