Considering the important applications of nitrogen-containing compounds in agrochemical materials and biomolecular drug molecules, research on methods for the construction of C–N bonds quickly and efficiently has become an important topic in synthetic chemistry. Carboxylic acids are inexpensive, stable, and non-toxic substances that are widely present in Nature, which makes them appealing as potential coupling partners for C(sp³)–N bond-forming reactions. Moreover, compared with the well-established transition-metal-catalyzed protocols, the rapid development of photoredox catalysis and electrochemical methods in recent years provides options for chemists to design new synthetic routes. In this short review, we concentrate on the decarboxylative C(sp³)–N coupling reactions mediated by visible light or electricity, with special attention on mechanistic insights.

中文翻译：

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光化学和电化学脱羧C（sp3）–N键形成的最新进展

考虑到含氮化合物在农业化学材料和生物分子药物分子中的重要应用，快速有效地构建C–N键的方法的研究已成为合成化学中的重要课题。羧酸是一种廉价，稳定且无毒的物质，在自然界中广泛存在，这使其成为C（sp ³）–N键形成反应的潜在偶联伙伴。而且，与完善的过渡金属催化方案相比，近年来光氧化还原催化和电化学方法的迅速发展为化学家设计新的合成路线提供了选择。在这篇简短的评论中，我们将重点讨论脱羧C（sp ³）–由可见光或电介导的N偶合反应，尤其要注意机理的见解。