Virtually all transport events at the Golgi complex are regulated by Arf and Rab family GTPases. Recent work has advanced our knowledge regarding the mechanisms controlling GTPase activity, and it has become clear that GTPases do not act in isolation but rather function in complex networks of crosstalk and feedback. Together with earlier findings, these recent studies indicate that communication between GTPases, their regulatory proteins, effectors, and lipids plays a pivotal role in Golgi transport and cisternal maturation.

中文翻译：

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广泛的 GTPase 串扰调节高尔基体的运输和成熟。

实际上，高尔基复合体中的所有运输事件都受 Arf 和 Rab 家族 GTP 酶的调控。最近的工作使我们对控制 GTPase 活性的机制有了更深入的了解，并且很明显 GTPases 不会孤立地起作用，而是在复杂的串扰和反馈网络中起作用。连同早期的发现，这些最近的研究表明 GTP 酶、它们的调节蛋白、效应物和脂质之间的通讯在高尔基体转运和脑池成熟中起着关键作用。