This report was produced by an Expert Working Group (EWG) consisting of UK-based researchers, veterinarians and regulators of animal experiments with specialist knowledge of the use of animal models of spinal cord injury (SCI). It aims to facilitate the implementation of the Three Rs (Replacement, Reduction and Refinement), with an emphasis on refinement. Specific animal welfare issues were identified and discussed, and practical measures proposed, with the aim of reducing animal use and suffering, reducing experimental variability, and increasing translatability within this critically important research field.

中文翻译：

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提炼脊髓损伤的啮齿动物模型

这份报告是由专家工作组（EWG）制作的，该工作组由英国研究人员，兽医和动物实验管理人员组成，他们对使用脊髓损伤（SCI）动物模型具有专业知识。它旨在促进实施三个R（替代，减少和完善），并着重于完善。确定并讨论了特定的动物福利问题，并提出了切实可行的措施，目的是在这个至关重要的研究领域中减少动物的使用和痛苦，减少实验变异性并提高可翻译性。