Longitudinal survey of microbiome associated with particulate matter in a megacity,Genome Biology

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Longitudinal survey of microbiome associated with particulate matter in a megacity
Genome Biology ( IF 12.3 ) Pub Date : 2020-03-03 , DOI: 10.1186/s13059-020-01964-x
Nan Qin _{1,

2} , Peng Liang _{3,

4} , Chunyan Wu ₂ , Guanqun Wang ₄ , Qian Xu _{1,

2} , Xiao Xiong ₂ , Tingting Wang ₂ , Moreno Zolfo ₅ , Nicola Segata ₅ , Huanlong Qin ₁ , Rob Knight _{6,

7,

8} , Jack A Gilbert _{6,

8,

9} , Ting F Zhu ₄

Affiliation

Institute of Intestinal Diseases, Department of General Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.
Realbio Genomics Institute, Shanghai, 200050, China.
School of Life Sciences, Peking University, Beijing, 100871, China.
School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, Center for Synthetic and Systems Biology, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education Key Laboratory of Bioinformatics, Tsinghua University, Beijing, 100084, China.
Centre for Integrative Biology, University of Trento, 38123, Trento, Italy.
Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA.
Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA.
Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093, USA.

Background While the physical and chemical properties of airborne particulate matter (PM) have been extensively studied, their associated microbiome remains largely unexplored. Here, we performed a longitudinal metagenomic survey of 106 samples of airborne PM 2.5 and PM 10 in Beijing over a period of 6 months in 2012 and 2013, including those from several historically severe smog events. Results We observed that the microbiome composition and functional potential were conserved between PM 2.5 and PM 10 , although considerable temporal variations existed. Among the airborne microorganisms, Propionibacterium acnes , Escherichia coli , Acinetobacter lwoffii , Lactobacillus amylovorus , and Lactobacillus reuteri dominated, along with several viral species. We further identified an extensive repertoire of genes involved in antibiotic resistance and detoxification, including transporters, transpeptidases, and thioredoxins. Sample stratification based on Air Quality Index (AQI) demonstrated that many microbial species, including those associated with human, dog, and mouse feces, exhibit AQI-dependent incidence dynamics. The phylogenetic and functional diversity of air microbiome is comparable to those of soil and water environments, as its composition likely derives from a wide variety of sources. Conclusions Airborne particulate matter accommodates rich and dynamic microbial communities, including a range of microbial elements that are associated with potential health consequences.

更新日期：2020-03-03

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