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Advanced biomaterials for cancer immunotherapy.
Acta Pharmacologica Sinica ( IF 8.2 ) Pub Date : 2020-03-02 , DOI: 10.1038/s41401-020-0372-z
Fan Yang 1 , Kun Shi 1 , Yan-Peng Jia 1 , Ying Hao 1 , Jin-Rong Peng 1 , Zhi-Yong Qian 1
Affiliation  

Immunotherapy, as a powerful strategy for cancer treatment, has achieved tremendous efficacy in clinical trials. Despite these advancements, there is much to do in terms of enhancing therapeutic benefits and decreasing the side effects of cancer immunotherapy. Advanced nanobiomaterials, including liposomes, polymers, and silica, play a vital role in the codelivery of drugs and immunomodulators. These nanobiomaterial-based delivery systems could effectively promote antitumor immune responses and simultaneously reduce toxic adverse effects. Furthermore, nanobiomaterials may also combine with each other or with traditional drugs via different mechanisms, thus giving rise to more accurate and efficient tumor treatment. Here, an overview of the latest advancement in these nanobiomaterials used for cancer immunotherapy is given, describing outstanding systems, including lipid-based nanoparticles, polymer-based scaffolds or micelles, inorganic nanosystems, and others.

中文翻译:

用于癌症免疫治疗的先进生物材料。

免疫疗法作为一种强有力的癌症治疗策略,在临床试验中取得了巨大的疗效。尽管取得了这些进展,但在增强癌症免疫疗法的治疗效果和减少副作用方面还有很多工作要做。先进的纳米生物材料,包括脂质体、聚合物和二氧化硅,在药物和免疫调节剂的协同递送中发挥着至关重要的作用。这些基于纳米生物材料的递送系统可以有效促进抗肿瘤免疫反应,同时减少毒性副作用。此外,纳米生物材料还可以通过不同的机制相互结合或与传统药物结合,从而实现更准确、更有效的肿瘤治疗。在这里,概述了这些用于癌症免疫治疗的纳米生物材料的最新进展,描述了杰出的系统,包括基于脂质的纳米粒子、基于聚合物的支架或胶束、无机纳米系统等。
更新日期:2020-04-24
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