### [Chang et al. Page 731][1] Malignant sarcomas, such as MPNST, Ewing sarcoma, and osteosarcoma, are highly refractory to current treatments. We identified two silvestrol-related eIF4A inhibitors, rocaglamide (Roc) and didesmethylrocaglamide, with comparable antiproliferative activity and the

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### [Chang等。Page 731] [1]恶性肉瘤，例如MPNST，尤因肉瘤和骨肉瘤，对目前的治疗方法具有很高的抵抗力。我们确定了两种与silvestrol相关的eIF4A抑制剂罗格列酰胺（Roc）和双二甲基罗格列酰胺，它们具有相当的抗增殖活性，并且