Inflammation is a colorectal cancer (CRC) hallmark. Inflammasome-dependent cytokines IL-1ß and IL-18 can play a beneficial or detrimental role in tumorigenesis depending on cancer type. Variants in inflammasome genes were associated with tumor development and/or outcome, and have been proposed as potential biomarkers for population screening.

In this study, 215 CRC patients followed-up for 10 years were examined for 9 polymorphisms in selected inflammasome genes. Multivariate association analysis and survival analysis were performed to evaluate the association between the polymorphisms and CRC prognosis.

Variants associated with lower levels of IL-18 (rs1834481, rs5744256), or with increased activation of inflammasome receptors NLRP1 (rs12150220) and NLRP3 (rs35829419) resulted detrimental to CRC prognosis and may be used as prognostic markers.

炎症是结直肠癌（CRC）的标志。依赖于炎症小体的细胞因子IL-1ß和IL-18在肿瘤发生中可能起有益作用或有害作用，具体取决于癌症类型。炎性体基因的变异与肿瘤的发展和/或结局有关，并已被提议作为人群筛选的潜在生物标记。

在这项研究中，对215名CRC患者进行了10年的随访，检查了所选炎性体基因中的9种多态性。进行多变量关联分析和生存分析，以评估多态性与CRC预后之间的关联。

与IL-18水平较低（ rs1834481，rs5744256）或炎症小体受体NLRP1（rs12150220）和NLRP3（rs35829419）活化相关的变体对CRC预后有害，可用作预后标志物。