Deubiquitinases are enzymes that remove ubiquitin moieties from the vast majority of cellular proteins, controlling their stability, interactions, and localization. The expression and activity of deubiquitinases are critical for physiology and can go awry in various diseases, including cancer. Based on recent findings in human blood cancers, we discuss the functions of selected deubiquitinases in acute leukemia and efforts to target these enzymes with the aim of blocking leukemia growth and improving disease outcomes. We focus on the emergence of the newest generation of preclinical inhibitors by discussing their modes of inhibition and their effects on leukemia biology.

中文翻译：

---

去泛素酶：血液恶性肿瘤中促癌活性和靶向治疗。

去泛素酶是从绝大多数细胞蛋白中去除泛素部分，控制其稳定性，相互作用和定位的酶。去泛素酶的表达和活性对于生理至关重要，并且可以在包括癌症在内的各种疾病中失灵。基于人类血液癌的最新发现，我们讨论了选定的去泛素酶在急性白血病中的功能以及针对这些酶的作用，旨在阻断白血病的生长并改善疾病的预后。通过讨论它们的抑制方式及其对白血病生物学的影响，我们集中于最新一代的临床前抑制剂的出现。