Type 1 diabetes (T1D) patients show lipid disorders which are likely to play a role in their increased cardiovascular (CV) disease risk. Quantitative abnormalities of lipoproteins are noted in T1D with poor glycemic control. In T1D with optimal glycemic control, triglycerides and LDL-cholesterol are normal or slightly decreased whereas HDL-cholesterol is normal or slightly increased. T1D patients, even with good glycemic control, show several qualitative and functional abnormalities of lipoproteins that are potentially atherogenic. An association between these abnormalities and CV disease risk has been reported in recent studies. Although the mechanisms underlying T1D dyslipidemia remain unclear, the subcutaneous route of insulin administration, that is responsible for peripheral hyperinsulinemia, is likely to be an important factor.

中文翻译：

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1 型糖尿病中的血脂异常：隐藏的危险

1 型糖尿病 (T1D) 患者表现出脂质紊乱，这可能在其心血管 (CV) 疾病风险增加中发挥作用。在血糖控制不佳的 T1D 中注意到脂蛋白的定量异常。在具有最佳血糖控制的 T1D 中，甘油三酯和 LDL-胆固醇正常或略有下降，而 HDL-胆固醇正常或略有升高。T1D 患者，即使血糖控制良好，也会显示出几种可能导致动脉粥样硬化的脂蛋白质量和功能异常。最近的研究报告了这些异常与心血管疾病风险之间的关联。尽管 T1D 血脂异常的潜在机制尚不清楚，但皮下注射胰岛素的途径可能是导致外周高胰岛素血症的一个重要因素。