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Prevalence of Hypokalemia and Primary Aldosteronism in 5100 Patients Referred to a Tertiary Hypertension Unit
Hypertension ( IF 8.3 ) Pub Date : 2020-04-01 , DOI: 10.1161/hypertensionaha.119.14063
Jacopo Burrello 1 , Silvia Monticone 1 , Isabel Losano 1 , Giovanni Cavaglià 1 , Fabrizio Buffolo 1 , Martina Tetti 1 , Michele Covella 1 , Franco Rabbia 1 , Franco Veglio 1 , Barbara Pasini 2 , Tracy Ann Williams 1, 3 , Paolo Mulatero 1
Affiliation  

Supplemental Digital Content is available in the text. Primary aldosteronism (PA) was considered a rare disorder almost always associated with hypokalemia. The widespread screening of patients with hypertension unveiled an increased prevalence of PA with normokalemic hypertension the prevailing phenotype. Many studies have reported the prevalence of hypokalemia in patients with PA; conversely, the prevalence of PA in patients with hypokalemia is unknown. In this retrospective observational study, we define the prevalence of hypokalemia in referred patients with hypertension and the prevalence of PA in patients with hypokalemia and hypertension. Hypokalemia was present in 15.8% of 5100 patients with hypertension, whereas 76.9% were normokalemic, and 7.3% hyperkalemic. The prevalence of PA in patients with hypokalemia was 28.1% and increased with decreasing potassium concentrations up to 88.5% of patients with spontaneous hypokalemia and potassium concentrations <2.5 mmol/L. A multivariate regression analysis demonstrated the association of hypokalemia with the occurrence of cardiovascular events independent of PA diagnosis. An association of PA with the occurrence of cardiovascular events and target organ damage independent of hypokalemia was also demonstrated. In conclusion, our results confirm that PA is a frequent cause of secondary hypertension in patients with hypokalemia, and the presence of hypertension and spontaneous hypokalemia are strong indications for PA diagnosis. Finally, we show that PA and hypokalemia are associated with an increased risk of cardiovascular events.

中文翻译:

转诊至三级高血压病房的 5100 名患者的低钾血症和原发性醛固酮增多症患病率

补充数字内容在文本中可用。原发性醛固酮增多症 (PA) 被认为是一种罕见的疾病,几乎总是与低钾血症有关。对高血压患者的广泛筛查揭示了以正常血钾型高血压为主要表型的 PA 患病率增加。许多研究报告了 PA 患者低钾血症的患病率;相反,低钾血症患者中 PA 的患病率尚不清楚。在这项回顾性观察性研究中,我们定义了高血压转诊患者中低钾血症的患病率,以及低钾血症和高血压患者中 PA 的患病率。5100 名高血压患者中有 15.8% 存在低钾血症,而 76.9% 为正常钾血症,7.3% 为高钾血症。低钾血症患者中 PA 的患病率为 28。1% 并且随着钾浓度的降低而增加,高达 88.5% 的自发性低钾血症和钾浓度 <2.5 mmol/L 的患者。多变量回归分析表明,低钾血症与心血管事件的发生有关,而与 PA 诊断无关。还证明了 PA 与心血管事件和靶器官损伤的发生之间的关联,而与低钾血症无关。总之,我们的研究结果证实,PA 是低钾血症患者继发性高血压的常见原因,高血压和自发性低钾血症的存在是 PA 诊断的有力指征。最后,我们表明 PA 和低钾血症与心血管事件风险增加有关。5% 的患者出现自发性低钾血症且钾浓度 <2.5 mmol/L。多变量回归分析表明,低钾血症与心血管事件的发生有关,而与 PA 诊断无关。还证明了 PA 与心血管事件和靶器官损伤的发生之间的关联,而与低钾血症无关。总之,我们的结果证实 PA 是低钾血症患者继发性高血压的常见原因,高血压和自发性低钾血症的存在是 PA 诊断的有力指征。最后,我们表明 PA 和低钾血症与心血管事件风险增加有关。5% 的患者出现自发性低钾血症且钾浓度 <2.5 mmol/L。多变量回归分析表明,低钾血症与心血管事件的发生有关,而与 PA 诊断无关。还证明了 PA 与心血管事件和靶器官损伤的发生之间的关联,而与低钾血症无关。总之,我们的结果证实 PA 是低钾血症患者继发性高血压的常见原因,高血压和自发性低钾血症的存在是 PA 诊断的有力指征。最后,我们表明 PA 和低钾血症与心血管事件风险增加有关。多变量回归分析表明,低钾血症与心血管事件的发生有关,而与 PA 诊断无关。还证明了 PA 与心血管事件和靶器官损伤的发生之间的关联,而与低钾血症无关。总之,我们的结果证实 PA 是低钾血症患者继发性高血压的常见原因,高血压和自发性低钾血症的存在是 PA 诊断的有力指征。最后,我们表明 PA 和低钾血症与心血管事件风险增加有关。多变量回归分析表明,低钾血症与心血管事件的发生有关,而与 PA 诊断无关。还证明了 PA 与心血管事件和靶器官损伤的发生之间的关联,而与低钾血症无关。总之,我们的结果证实 PA 是低钾血症患者继发性高血压的常见原因,高血压和自发性低钾血症的存在是 PA 诊断的有力指征。最后,我们表明 PA 和低钾血症与心血管事件风险增加有关。我们的结果证实 PA 是低钾血症患者继发性高血压的常见原因,高血压和自发性低钾血症的存在是 PA 诊断的有力指征。最后,我们表明 PA 和低钾血症与心血管事件风险增加有关。我们的结果证实 PA 是低钾血症患者继发性高血压的常见原因,高血压和自发性低钾血症的存在是 PA 诊断的有力指征。最后,我们表明 PA 和低钾血症与心血管事件风险增加有关。
更新日期:2020-04-01
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