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Design, synthesis, and characterization of some new benzimidazole derivatives and biological evaluation
Journal of Heterocyclic Chemistry ( IF 2.4 ) Pub Date : 2020-03-01 , DOI: 10.1002/jhet.3943
Hakan Bektaş 1 , Bahar B. Sökmen 1 , Sinem Aydın 2 , Emre Menteşe 3 , Adile Bektaş 1 , Gamze Dilekçi 1
Affiliation  

A new series of benzimidazole derivatives (1‐15) containing 1,2,4‐triazole, 1,3,4‐thiadiazole, 1,3,4‐oxadiazole, and thiazolidinon rings have been synthesized. All new synthesized benzimidazole compounds were confirmed by 1H NMR, 13C NMR spectra, and LC‐MS, and they were examined for their antioxidant and antimicrobial activities. Compounds 7 and 1 showed the highest and the lowest antioxidant activities, respectively. The lowest minimum inhibition concentration value found in compound 5 against Enterobacter aerogenes.

中文翻译:

一些新型苯并咪唑衍生物的设计,合成,表征及生物学评价

合成了一系列新的苯并咪唑衍生物(1-15),其中含有1,2,4-三唑,1,3,4-噻二唑,1,3,4-恶二唑和噻唑烷酮环。所有新合成的苯并咪唑化合物均通过1 H NMR,13 C NMR光谱和LC-MS确认,并检查了它们的抗氧化和抗菌活性。化合物71分别显示出最高和最低的抗氧化活性。化合物5对产气肠杆菌的最低最低抑菌浓度值。
更新日期:2020-03-01
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