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Current understanding of substrate specificity and regioselectivity of LPMOs
Bioresources and Bioprocessing ( IF 4.6 ) Pub Date : 2020-03-02 , DOI: 10.1186/s40643-020-0300-6
Xiaoli Zhou , Honghui Zhu

Renewable biomass such as cellulose and chitin are the most abundant sustainable sources of energy and materials. However, due to the low degradation efficiency of these recalcitrant substrates by conventional hydrolases, these biomass resources cannot be utilized efficiently. In 2010, the discovery of lytic polysaccharide monooxygenases (LPMOs) led to a major breakthrough. Currently, LPMOs are distributed in 7 families in CAZy database, including AA9–11 and AA13–16, with different species origins, substrate specificity and oxidative regioselectivity. Effective application of LPMOs in the biotransformation of biomass resources needs the elucidation of the molecular basis of their function. Since the discovery of LPMOs, great advances have been made in the study of their substrate specificity and regioselectivity, as well as their structural basis, which will be reviewed below.

中文翻译:

目前对LPMO底物特异性和区域选择性的了解

纤维素和几丁质等可再生生物质是最丰富的可持续能源和材料来源。然而,由于常规水解酶对这些难降解底物的降解效率低,所以这些生物质资源不能得到有效利用。2010年,裂解多糖单加氧酶(LPMO)的发现带来了重大突破。目前,LPMOs分布在CAZy数据库的7个科中,包括AA9-11和AA13-16,具有不同的物种起源,底物特异性和氧化区域选择性。LPMO在生物质资源的生物转化中的有效应用需要阐明其功能的分子基础。自从发现LPMO以来,在研究其底物特异性和区域选择性以及它们的结构基础方面取得了很大的进步,
更新日期:2020-03-02
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