AIMS Insomnia, intelligence and neuroticism are three typical traits and dysfunctions mainly regulated by human brain. Our research aimed to explore the potential genetic relationships between brain function related traits and more than 3000 human plasma proteins. MATERIALS AND METHODS We conducted a large-scale genetic correlation scan of human plasma proteins and three brain function related traits, including insomnia, intelligence and neuroticism. Linkage disequilibrium score regression (LDSC) analysis was performed to estimate the genetic correlations between each of the blood proteins and insomnia, intelligence and neuroticism via utilizing the genome-wide association study summary statistics of plasma proteins and those three traits. RESULTS LDSC analysis identified 18 specific plasma proteins shown suggestive genetic correlations with insomnia such as Periostin (coefficient=-0.3910, P value = 0.0070). Twenty-one plasma proteins exhibited genetic correlations with intelligence such as Ecto-ADP-ribosyltransferase 3 (coefficient = 0.3066, P value = 0.0013). Six specific plasma proteins shown suggestive genetic correlations with neuroticism, such as CD70 antigen (coefficient = 0.2979, P value = 0.0134). After further comparing the suggestive proteins between insomnia, intelligence and neuroticism, we detected 3 common plasma proteins shared by insomnia and intelligence such as Periostin (coefficient insomnia =-0.3910, Pinsomnia value = 0.0070; coefficient intelligence =0.2673, Pintelligence value = 0.0159) and Neurexin-1 (coefficient insomnia =-0.2913, Pinsomnia value = 0.0197; coefficient intelligence = 0.2399, Pintelligence value = 0.0035). We also detected 2 common plasma proteins shared by intelligence and neuroticism, including CD70 antigen (coefficient intelligence =-0.2092, Pintelligence value = 0.0337; coefficient neuroticism = 0.2979, Pneuroticism value = 0.0134). CONCLUSION Our results provide novel clues for unveiling the functional relevance of plasma proteins and brain function related traits.

中文翻译：

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大规模遗传相关扫描确定了与脑功能相关特征相关的血浆蛋白。

AIMS 失眠、智力和神经质是主要受人脑调节的三种典型特征和功能障碍。我们的研究旨在探索大脑功能相关性状与 3000 多种人类血浆蛋白之间的潜在遗传关系。材料与方法 我们对人类血浆蛋白和三个与大脑功能相关的特征（包括失眠、智力和神经质）进行了大规模的遗传相关扫描。通过利用血浆蛋白和这三个特征的全基因组关联研究汇总统计，进行连锁不平衡评分回归 (LDSC) 分析以估计每种血液蛋白与失眠、智力和神经质之间的遗传相关性。结果 LDSC 分析确定了 18 种特定的血浆蛋白，显示出与失眠症的暗示性遗传相关性，例如骨膜蛋白（系数 =-0.3910，P 值 = 0.0070）。21 种血浆蛋白表现出与智力的遗传相关性，例如 Ecto-ADP-核糖基转移酶 3（系数 = 0.3066，P 值 = 0.0013）。六种特定的血浆蛋白显示出与神经质的暗示性遗传相关性，例如 CD70 抗原（系数 = 0.2979，P 值 = 0.0134）。在进一步比较失眠、智力和神经质之间的提示蛋白后，我们检测了失眠和智力共有的3种常见血浆蛋白，如Periostin（失眠系数=-0.3910，Pinsomnia值=0.0070；智力系数=0.2673，Pintelligence值=0.0159）和Neurexin-1（失眠系数=-0.2913，Pinsomnia值=0.0197；系数智能 = 0.2399，Pintelligence 值 = 0.0035）。我们还检测了智力和神经质共有的2种常见血浆蛋白，包括CD70抗原（智力系数=-0.2092，Pintelligence值=0.0337；神经质系数=0.2979，神经质值=0.0134）。结论我们的结果为揭示血浆蛋白和脑功能相关特征的功能相关性提供了新的线索。