Although the need for non-animal alternatives has been well recognised for the human health hazard assessment of chemicals in general, it has become especially pressing for cosmetic ingredients due to the full implementation of testing and marketing bans on animal testing under the European Cosmetic Regulation. This means that for the safety assessment of cosmetics, the necessary safety data for both the ingredients and the finished product can be drawn from validated (or scientifically-valid), so-called "Replacement methods". In view of the challenges for safety assessment without recourse to animal test data, the Methodology Working Group of the Scientific Committee on Consumer Safety organised a workshop in February 2019 to discuss the key issues in regard to the use of animal-free alternative methods for the safety evaluation of cosmetic ingredients. This perspective article summarises the outcomes of this workshop and reflects on the state-of-the-art and possible way forward for the safety assessment of cosmetic ingredients for which no experimental animal data exist. The use and optimisation of "New Approach Methodologies" that could be useful tools in the context of the "Next Generation Risk Assessment and the strategic framework for safety assessment of cosmetics were discussed in depth.

中文翻译：

---

欧盟评估化妆品对人体健康安全的未来方法-研讨会程序。

尽管对于一般化学品对人类健康的危害评估，非动物替代品的需求已得到公认，但由于全面实施了《欧洲化妆品法规》对动物测试的测试和销售禁令，对化妆品成分的压力尤其迫切。这意味着，对于化妆品的安全性评估，可以从经过验证的（或科学上有效的）所谓的“替换方法”中提取成分和成品的必要安全性数据。鉴于在不依靠动物实验数据的情况下进行安全评估的挑战，消费者安全科学委员会的方法学工作组于2019年2月组织了一个研讨会，讨论了使用无动物替代方法进行化妆品成分安全性评估的关键问题。这篇有远见的文章总结了这次研讨会的成果，并反思了目前尚无动物实验数据的化妆品成分安全性评估的最新技术和可能的前进方向。深入讨论了在“下一代风险评估和化妆品安全性评估战略框架”中可能有用的工具“新方法”的使用和优化。这篇有远见的文章总结了这次研讨会的成果，并反思了目前尚无动物实验数据的化妆品成分安全性评估的最新技术和可能的前进方向。深入讨论了在“下一代风险评估和化妆品安全性评估战略框架”中可能有用的工具“新方法”的使用和优化。这篇有远见的文章总结了这次研讨会的成果，并反思了目前尚无动物实验数据的化妆品成分安全性评估的最新技术和可能的前进方向。深入讨论了在“下一代风险评估和化妆品安全性评估战略框架”中可能有用的工具“新方法”的使用和优化。