Abstract As it is known, microreactors are an important development in chemical engineering since the pharmaceutical industry needs flexible production rather than a large amount of product yield. In this paper, we propose the design of a continuous-flow microreactor in the form of a narrow cell with an adjustable gap. By tuning the gap width in time and space, one can control the reaction rate and regulate the product yield. We show that the governing equation for the fluid flow can be reduced to the Darcy equation with the permeability varying in space and time. As a benchmark reaction, we consider the neutralization of nitric acid with sodium hydroxide resulting in the solutal convection in the presence of gravity. We demonstrate numerically that the prototyping spatially-distributed relief of the reactor walls can successfully separate the incoming and outgoing flows of reagents, control the mixing intensity, increase or decrease the product yield. We show also the dynamic control of the reactor in operation via real-time local changes in the gap width.

中文翻译：

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控制具有可变壁面浮雕的连续流动微反应器中的传质

摘要 众所周知，微反应器是化学工程的重要发展，因为制药工业需要灵活的生产而不是大量的产品产量。在本文中，我们提出了一种具有可调间隙的窄池形式的连续流动微反应器的设计。通过在时间和空间上调整间隙宽度，可以控制反应速率并调节产物收率。我们表明，流体流动的控制方程可以简化为渗透率随空间和时间变化的达西方程。作为基准反应，我们考虑用氢氧化钠中和硝酸导致在重力存在下的溶质对流。我们通过数值证明反应器壁的原型空间分布浮雕可以成功地分离试剂的进出流，控制混合强度，增加或减少产品产量。我们还通过间隙宽度的实时局部变化展示了运行中反应器的动态控制。