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Carotenoids and carotenoid conversion products in adipose tissue biology and obesity: Pre-clinical and human studies.
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids ( IF 4.8 ) Pub Date : 2020-02-28 , DOI: 10.1016/j.bbalip.2020.158676
M Luisa Bonet 1 , Joan Ribot 1 , Sebastiá Galmés 2 , Francisca Serra 1 , Andreu Palou 1
Affiliation  

Antiobesity activities of carotenoids and carotenoid conversion products (CCPs) have been demonstrated in pre-clinical studies, and mechanisms behind have begun to be unveiled, thus suggesting these compounds may help obesity prevention and management. The antiobesity action of carotenoids and CCPs can be traced to effects in multiple tissues, notably the adipose tissues. Key aspects of the biology of adipose tissues appear to be affected by carotenoid and CCPs, including adipogenesis, metabolic capacities for energy storage, release and inefficient oxidation, secretory function, and modulation of oxidative stress and inflammatory pathways. Here, we review the connections of carotenoids and CCPs with adipose tissue biology and obesity as revealed by cell and animal intervention studies, studies addressing the role of endogenous retinoid metabolism, and human epidemiological and intervention studies. We also consider human genetic variability influencing carotenoid and vitamin A metabolism, particularly in adipose tissues, as a potentially relevant aspect towards personalization of dietary recommendations to prevent or manage obesity and optimize metabolic health. This article is part of a Special Issue entitled Carotenoids recent advances in cell and molecular biology edited by Johannes von Lintig and Loredana Quadro.



中文翻译:

脂肪组织生物学和肥胖症中的类胡萝卜素和类胡萝卜素转化产品:临床前和人体研究。

临床前研究已经证明了类胡萝卜素和类胡萝卜素转化产物(CCPs)的抗肥胖作用,并且其背后的机制也已开始揭示,因此表明这些化合物可能有助于肥胖症的预防和治疗。类胡萝卜素和CCP的抗肥胖作用可以追溯到多种组织,特别是脂肪组织中的作用。脂肪组织生物学的关键方面似乎受到类胡萝卜素和CCP的影响,包括脂肪形成,能量存储的代谢能力,释放和无效的氧化,分泌功能以及氧化应激和炎症途径的调节。在这里,我们回顾了细胞和动物干预研究揭示的类胡萝卜素和CCP与脂肪组织生物学和肥胖症的联系,这些研究涉及内源性类维生素A代谢的作用,以及人类流行病学和干预研究。我们还认为,影响类胡萝卜素和维生素A代谢(尤其是在脂肪组织中)的人类遗传变异性可能与个性化饮食建议有关,以预防或控制肥胖并优化代谢健康。本文是由约翰内斯·冯·林提格(Johannes von Lintig)和洛雷丹娜·夸德罗(Loredana Quadro)编辑的《类胡萝卜素在细胞和分子生物学领域的最新进展》特刊的一部分。

更新日期:2020-02-28
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