Abstract Mefenamic acid and indomethacin, medicaments belonging to the group of non-steroidal anti-inflammatory agents, were determined separately and simultaneously at anodically prepared BDDE. Differential pulse voltammetry was used to establish simple and fast analytical procedure based on electrooxidation of mefenamic acid at 0.6 V and indomethacin at 1.0 V (and 1.1 V). At optimal conditions, it was suitable for highly sensitive and selective determination of these compounds with LODs comparable to previously reported modified electrodes. Additionally, considering the importance of these compounds, we proposed precise and accurate quantification of these species based on green and simple pre-treatable electrochemical sensor. The effect of interfering agents (tablet ingredients and vitamins) was appeared to be negligibly confirming a favourable selectivity of the method. The proposed method was analytically applied by simultaneously determining mefenamic acid and indomethacin in pharmaceutical formulations.

中文翻译：

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掺硼金刚石电极作为同时定量甲芬那酸和吲哚美辛的高效传感平台

摘要 甲芬那酸和吲哚美辛属于非甾体抗炎药，在阳极制备的 BDDE 上分别同时测定。基于甲芬那酸在 0.6 V 和吲哚美辛在 1.0 V（和 1.1 V）的电氧化，使用差示脉冲伏安法建立简单快速的分析程序。在最佳条件下，它适用于这些化合物的高灵敏度和选择性测定，其 LOD 与之前报道的修饰电极相当。此外，考虑到这些化合物的重要性，我们提出了基于绿色和简单的可预处理电化学传感器对这些物种进行精确和准确的量化。干扰剂（片剂成分和维生素）的影响似乎微不足道，证实了该方法的良好选择性。通过同时测定药物制剂中的甲芬那酸和吲哚美辛，对所提出的方法进行了分析应用。