Microbial contamination of polymer surfaces has become a significant challenge in domestic, industrial, and biomedical applications. Recent progress in our understanding of how topographical features of different length scales can be used to effectively and selectively control the attachment and proliferation of different cell types has provided an alternative strategy for imparting antibacterial activity to these surfaces. Among the well-recognized engineered models of antibacterial surface topographies, self-organized wrinkles have shown particular promise with respect to their antimicrobial characteristics. Here, we critically review the mechanisms by which wrinkles form on the surface of different types of polymer material and how they interact with various biomolecules and cell types. We also discuss the feasibility of using this antimicrobial strategy in real-life biomedical applications.

中文翻译：

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聚合物薄膜上的三维分层皱纹：从无序到有序的抗菌拓扑结构。

聚合物表面的微生物污染已成为家庭、工业和生物医学应用中的重大挑战。我们对如何使用不同长度尺度的地形特征来有效和选择性地控制不同细胞类型的附着和增殖的理解的最新进展，为赋予这些表面抗菌活性提供了一种替代策略。在公认的抗菌表面形貌工程模型中，自组织皱纹在其抗菌特性方面表现出特别的希望。在这里，我们批判性地回顾了在不同类型聚合物材料表面形成皱纹的机制以及它们如何与各种生物分子和细胞类型相互作用。