Use of a directing group in C–H functionalizations, often referred to as chelation assistance, is one of the most reliable methods for achieving highly efficient and highly site-selective reactions. Although a variety of transition metals can be used in directed C–H functionalization reactions, Ni-catalyzed directed C–H functionalization reactions have remained a relatively underdeveloped area of research. Recently, interest in these reactions has been renewed due to the development of a combination of a Ni catalyst and an N,N′-bidentate group; the method is now emerging as a powerful tool for Ni-catalyzed C–H functionalization reactions. However, Ni-catalyzed C–H functionalizations that do not require the use of a specific directing group (e.g., N,N′-bidentate groups) have recently been reported. Thus, Ni-catalyzed C–H functionalizations have now reached a new and interesting stage.

在C–H功能化中使用导向基团（通常称为螯合辅助）是实现高效和高位点选择性反应的最可靠方法之一。尽管多种过渡金属可用于定向C–H官能化反应，但Ni催化的定向C–H官能化反应仍是一个相对欠发达的研究领域。近来，由于开发了Ni催化剂和N，N′-双齿基团的组合，人们对这些反应的兴趣再次提高。该方法现在正在成为镍催化的CHH功能化反应的有力工具。但是，镍催化的CH官能团不需要使用特定的导向基团（例如，N，N'-双齿组）最近已有报道。因此，Ni催化的C–H官能化现已进入一个新的有趣的阶段。