ABSTRACT Cucurbit[6]uril-based polymer nanocapsules (CB[6]PNs), covalently conjugated with a near-infrared dye (Cy 7), was exploited as a stable platform (Cy7-CB[6]PNs) for in vivo cancer targeting. The strong host-guest interaction between CB[6] and spermidine (spmd) enabled us to modify the surface of the nanocapsules with spmd-conjugated cancer targeting functional tags in a facile, controllable and non-covalent manner. Thanks to the strong host-guest interaction retained even in the bloodstream of a mouse, enhanced accumulation of Cy7-CB[6]PNs on cancer tissues of mice was successfully detected via NIR imaging when the nanocapsules were treated with more number of the cancer targeting functional tags. This result showed the potential of the CB[6]-based strong host-guest interaction as a controllable and efficient tool for surface modification of in vivo cancer targeting nanomaterials. Graphical abstract Enhanced accumulation of structurally stable cucurbit[6]uril-based polymer nanocapsules (CB[6]PNs) in a cancer tissue of mice was visualized by near-infrared fluorescence imaging, which demonstrated the potential of the CB[6]-based strong host-guest interaction as a practical and efficient tool for surface modification of in vivo targeting nanomaterials.

中文翻译：

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强大的主客体相互作用使葫芦[6]uril基聚合物纳米胶囊的表面修饰变得容易和可控，用于体内癌症靶向

摘要 葫芦[6]脲基聚合物纳米胶囊（CB[6]PNs）与近红外染料（Cy 7）共价结合，被用作体内癌症的稳定平台（Cy7-CB[6]PNs）目标。CB[6] 和亚精胺 (spmd) 之间强的主客体相互作用使我们能够以一种简便、可控和非共价的方式用 spmd 偶联的癌症靶向功能标签修饰纳米胶囊的表面。由于即使在小鼠的血流中也保留了强烈的宿主 - 客体相互作用，当纳米胶囊用更多的癌症靶向治疗时，通过 NIR 成像成功检测到 Cy7-CB[6]PNs 在小鼠癌症组织上的增强积累功能标签。这一结果表明基于 CB[6] 的强主客体相互作用作为体内癌症靶向纳米材料表面改性的可控和有效工具的潜力。图形摘要通过近红外荧光成像观察小鼠癌组织中结构稳定的葫芦 [6] 脲基聚合物纳米胶囊 (CB[6]PNs) 的增强积累，这证明了基于 CB[6] 的聚合物纳米胶囊的潜力强大的主客体相互作用作为体内靶向纳米材料表面改性的实用且有效的工具。