ABSTRACT Amino acid derived macrocycles with elaborate well-defined stereochemistry are a unique class of compounds that have been isolated from natural sources. Macrocycles like cyclosporine, octreotide, and valinomycin have been used in multiple applications, like drugs or ion sensors. Chemists have long been fascinated by the unique molecular recognition capabilities of these macrocycles and tried to design synthetic analogs with similar functions. This article is focused on reviewing current research on amide and amino acid containing macrocycles that have been developed in research laboratories for biological recognition, specifically for anion sensing, ion transport, carbohydrate sensing, and peptide sensing. GRAPHICAL ABSTRACT

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含酰胺和氨基酸的合成大环化合物的生物学应用

摘要 氨基酸衍生的大环化合物具有精心定义的立体化学，是一类独特的化合物，已从天然来源中分离出来。大环化合物如环孢菌素、奥曲肽和缬氨霉素已被用于多种应用，如药物或离子传感器。长期以来，化学家一直对这些大环化合物独特的分子识别能力着迷，并试图设计具有相似功能的合成类似物。本文重点回顾目前在研究实验室开发的含酰胺和氨基酸的大环化合物的研究，用于生物识别，特别是阴离子传感、离子传输、碳水化合物传感和肽传感。图形概要