ABSTRACT Cucurbit[n]urils are rigid cage-molecules of pumpkin-like shape, made of n-glycoluril units, able to bind mainly neutral molecules and cations. In this work, we investigate the binding of three cucurbit[5]uril derivatives with dioxygen O2 and show that one of them, namely per-hydroxylated cucurbit[5]uril, (OH)10CB[5], is able to significantly bind dioxygen gas at physiological temperature, even in the presence of sodium chloride at the concentration of injectable solution in blood. As cucurbit[n]urils studied up to now reveal low toxicity, per-hydroxylated cucurbit[5]uril appears as a promising precursor to design a host able to transport O2 in a haemoglobin substitute solution. Graphical abstract Graphical Abstract

中文翻译：

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葫芦[5]脲衍生物作为氧载体

摘要 葫芦[n] urils 是南瓜状的刚性笼状分子，由 n-甘脲单元制成，能够主要结合中性分子和阳离子。在这项工作中，我们研究了三种葫芦 [5] 脲衍生物与分子氧 O2 的结合，并表明其中之一，即过羟基化葫芦 [5] 脲，(OH)10CB[5]，能够显着结合分子氧生理温度下的气体，即使在氯化钠存在的情况下，血液中的注射溶液浓度也是如此。由于迄今为止研究的葫芦 [n] 脲显示出低毒性，因此过羟基化葫芦 [5] 脲似乎是设计能够在血红蛋白替代溶液中运输 O2 的宿主的有前途的前体。图形摘要图形摘要